Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14434476 | 0.88 | PRKCZ (0.50) | PRKCZARMAPTTSHRHSD17B10 | |
| SCHEMBL17885748 | 0.86 | NOTUM (0.47) | ABL1NOTUMSIGMAR1KCNH2 | |
| SCHEMBL17885744 | 0.80 | NPC1 (0.41) | MAPTALDH1A1NPC1SIGMAR1RAB9A | |
| SCHEMBL16911575 | 0.80 | ESR1 (0.41) | PRKCZARMAPTALDH1A1HSD17B10 | |
| SCHEMBL29662548 | 0.79 | KMT2A (0.41) | PRKCZMAPTNPSR1KCNH2GAA | |
| SCHEMBL17688930 | 0.77 | NOTUM (0.43) | PRKCZMAPTALDH1A1CYP3A4NPSR1 | |
| SCHEMBL1600266 | 0.75 | NOTUM (0.49) | MAPTALDH1A1HSD17B10NPSR1NPC1 | |
| SCHEMBL10070684 | 0.75 | PRKCZ (0.49) | PRKCZALDH1A1SIGMAR1GAA | |
| SCHEMBL4199674 | 0.74 | PRKCZ (0.48) | PRKCZMAPTALDH1A1CYP3A4ABL1 | |
| SCHEMBL15011778 | 0.74 | PRKCZ (0.40) | PRKCZARALDH1A1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120088763-A1 | TRIAZOLOPYRIDINE DERIVATIVES AND THEIR THERAPEUTIC USE | CHIESI FARMACEUTICI S.P.A. (IT) | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088763-A1 | TRIAZOLOPYRIDINE DERIVATIVES AND THEIR THERAPEUTIC USE | CNKSR1, MOK, MAPK1 | PRKCZ 316/4885AR 2687/4885MAPT 4493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.