Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 8/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | NTMT1 | Q9BV86 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1696114 | 1.00 | CHRM2 (0.39) | CHRM2CHRM1CHRM3CHRM5CHRM4 | |
| SCHEMBL1696221 | 0.86 | CYP2D6 (0.43) | CHRM2CHRM1CHRM3CHRM5CHRM4 | |
| SCHEMBL1696085 | 0.85 | CHRM2 (0.51) | CHRM2CHRM1CHRM3CHRM5CHRM4 | |
| SCHEMBL1696230 | 0.77 | TSHR (0.42) | CHRM2CHRM1CHRM3CHRM5CHRM4 | |
| SCHEMBL1696246 | 0.77 | TSHR (0.42) | CHRM2CHRM1CHRM3CHRM5CHRM4 | |
| SCHEMBL16461576 | 0.73 | NTMT1 (0.39) | CHRM3NTMT1RAB9A | |
| SCHEMBL1695999 | 0.73 | NTMT1 (0.39) | CHRM3NTMT1RAB9A | |
| SCHEMBL1696267 | 0.73 | NTMT1 (0.39) | CHRM3NTMT1RAB9A | |
| SCHEMBL2486589 | 0.67 | CHRM2 (0.66) | CHRM2CHRM1CHRM3CHRM5CHRM4 | |
| SCHEMBL2487397 | 0.64 | CHRM2 (0.58) | CHRM2CHRM1CHRM3CHRM5CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585458-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | Chiesi Farmaceutici S.p.A. (IT) | 2013-05-01 | — | — | EP | disclosed |
| EP-2585457-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | Chiesi Farmaceutici S.p.A. (IT) | 2013-05-01 | — | — | EP | disclosed |
| WO-2011160918-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-12-29 | — | — | WO | disclosed |
| WO-2011160919-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-12-29 | — | — | WO | disclosed |