NTMT1

N-terminal Xaa-Pro-Lys N-methyltransferase 1 · Q9BV86 · NTMT1 on Sugi Atlas →

3,252 patent compounds predicted against NTMT1, 1,342 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Venglustat Venglustat (SCHEMBL12615329) 1.00 20/20
Venglustat Venglustat (SCHEMBL12615333) 1.00 20/20
SCHEMBL18309554 SCHEMBL18309554 1.00 20/20
SCHEMBL19407265 SCHEMBL19407265 1.00 20/20
Venglustat Venglustat (SCHEMBL19844439) 1.00 20/20
SCHEMBL15579449 SCHEMBL15579449 0.81 20/20
SCHEMBL19837241 SCHEMBL19837241 0.80 20/20
SCHEMBL12615324 SCHEMBL12615324 0.71 20/20
SCHEMBL12615326 SCHEMBL12615326 0.71 20/20
SCHEMBL12613996 SCHEMBL12613996 0.67 20/20
SCHEMBL18993502 SCHEMBL18993502 0.65 20/20
SCHEMBL12614566 SCHEMBL12614566 0.64 20/20
SCHEMBL12614569 SCHEMBL12614569 0.64 20/20
SCHEMBL18993552 SCHEMBL18993552 0.63 20/20
SCHEMBL16007827 SCHEMBL16007827 0.59 20/20
SCHEMBL16007828 SCHEMBL16007828 0.59 20/20
SCHEMBL19837255 SCHEMBL19837255 0.58 20/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL17504473) 0.58 20/20
SCHEMBL15578272 SCHEMBL15578272 0.58 20/20
SCHEMBL12614770 SCHEMBL12614770 0.58 20/20

Clinical trials — most relevant to NTMT1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Evaluating the Safety and Efficacy of Decitabine in the Treatment of XMEN Patients PHASE4NOT_YET_RECRUITING
Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor PHASE1/PHASE2NOT_YET_RECRUITING
NEO100 and High-Grade Meningioma PHASE2RECRUITING
Safety and Impact of Dasatinib on Viral Persistence and Inflammation in People With HIV Under Antiretroviral Treatment PHASE2COMPLETED
Temozolomide Monotherapy or in Combination With Olaparib in Patients With Triple Negative Breast Cancer (TNBC) PHASE2NOT_YET_RECRUITING
Phase I Trial of 4'-Thio-2'-Deoxycytidine (TdCyd) in Patients With Advanced Solid Tumors PHASE1COMPLETED
A Clinical Trial of CNCT19 Cells in the Treatment of CD19 Positive Relapsed or Refractory Acute Lymphoblastic Leukemia PHASE1COMPLETED
A Clinical Trial of CNCT19 Cells in the Treatment of CD19 Positive Relapsed or Refractory Diffuse Non-Hodgkin Lymphoma PHASE1COMPLETED
5-aza-4'-Thio-2'-Deoxycytidine (Aza-TdC) in People With Advanced Solid Tumors PHASE1RECRUITING
MYT1L Syndrome: a Rare Paediatric Genetic Syndrome Responsible for a Neurodevelopmental Disorder nanRECRUITING
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer nanUNKNOWN
Assessment Of Long Noncoding RNA CCAT1 In Colorectal Cancer Patients nanUNKNOWN
Thermogenic Silencer Regulatory Factors in Humans nanACTIVE_NOT_RECRUITING
The Molecular Pathogenesis Study of Cataract nanUNKNOWN
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients nanCOMPLETED
Investigate eNAMPT in Multiple Myeloma Biology and Establish Its Role in Disease Progression nanCOMPLETED
Human Requirements for the Nutrient Choline nanCOMPLETED
Clinical Trials Using HepatoKeeper Herbal Essentials to Treat Non-alcoholic Fatty Liver Disease and Metabolic Factors nanCOMPLETED
Development and Validation of an Online Neurobehavioral Evaluation Tool for PTEN Patients nanCOMPLETED
MD2, Cystatin C and DNA Methylation Tags as Serum Biomarkers for POCD. nanUNKNOWN
Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan nanENROLLING_BY_INVITATION
A Prospective Study of Molecular Detection of Salvageable Early Recurrent Nasopharyngeal Carcinoma After Radiotherapy nanCOMPLETED
Diagnosis of RSTS: Identification of the Acetylation Profiles as Epigenetic Markers for Assessing Causality of CREBBP and EP300 Variants. nanUNKNOWN
Natural History Study for Patients With Nemaline Myopathy in Spain nanRECRUITING
Muscle Tissue Bank for Muscular Dystrophy nanCOMPLETED
Telomeres Length in Israeli Fibrotic ILD Patients nanENROLLING_BY_INVITATION
Target of Suv420h1/2 in Hepatocytes nanRECRUITING
Association of SNPs in Long Intergenic Noncoding RNA 00511 (LINC00511) With Breast Cancer Among the Egyptian Population nanCOMPLETED
Investigation of the Genetic and Environmental Causes of Autism: a Multi-Center Study nanNOT_YET_RECRUITING
Studying The Role of Key Epigenetic Mediators in Breast Cancer Patients nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a NTMT1 binder may also engage these)

ProteinNameSimilarity
D2H163 1.000 D2H163 →
Q5BJX0 0.997 Q5BJX0 →
Q2T9N3 0.995 Q2T9N3 →
Q8R2U4 0.995 Q8R2U4 →
Q6NWX7 0.995 Q6NWX7 →
Q4KLE6 0.993 Q4KLE6 →
B1H2P7 0.992 B1H2P7 →
Q4KL94 0.988 Q4KL94 →
O13748 0.974 O13748 →
Q5M8E6 0.974 Q5M8E6 →
Q504A5 0.973 Q504A5 →
Q9VIK9 0.973 Q9VIK9 →
Q07G10 0.973 Q07G10 →
Q9UIC8 0.971 Q9UIC8 →
F4ZGF2 0.971 F4ZGF2 →
Q9N4D9 0.970 Q9N4D9 →
Q9DCS2 0.970 Q9DCS2 →
Q6NTR1 0.969 Q6NTR1 →
P38340 0.969 P38340 →
Q6AXU8 0.969 Q6AXU8 →
A8WVR2 0.968 A8WVR2 →
Q5ZIB9 0.968 Q5ZIB9 →
Q8BVH9 0.968 Q8BVH9 →
PRMT5 Protein arginine N-methyltransferase 5 0.968 landscape →
P17571 0.967 P17571 →
A8KBL7 0.967 A8KBL7 →
Q7ZW24 0.967 Q7ZW24 →
Q6NUA1 0.967 Q6NUA1 →
Q9URX7 0.967 Q9URX7 →
Q8R3P0 0.967 Q8R3P0 →