Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 11/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 9/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 9/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16377672 | 1.00 | CHRNA7 (0.54) | CHRNA7BCHEACHECHRM3CHRM2 | |
| SCHEMBL1696001 | 1.00 | CHRNA7 (0.54) | CHRNA7BCHEACHECHRM3CHRM2 | |
| Hydrochloric Acid SCHEMBL2485785 | 0.99 | CHRNA7 (0.53) | CHRNA7BCHEACHECHRM3CHRM2 | |
| Hydrochloric Acid SCHEMBL2485787 | 0.99 | CHRNA7 (0.53) | CHRNA7BCHEACHECHRM3CHRM2 | |
| SCHEMBL19894805 | 0.90 | CHRM3 (0.47) | CHRNA7BCHEACHECHRM3CHRM2 | |
| SCHEMBL12071819 | 0.84 | CHRM3 (0.62) | CHRNA7BCHEACHECHRM3CHRM2 | |
| SCHEMBL1695935 | 0.84 | CHRM3 (0.62) | CHRNA7BCHEACHECHRM3CHRM2 | |
| SCHEMBL1695933 | 0.84 | CHRM3 (0.62) | CHRNA7BCHEACHECHRM3CHRM2 | |
| SCHEMBL1695975 | 0.84 | CHRM3 (0.62) | CHRNA7BCHEACHECHRM3CHRM2 | |
| SCHEMBL2486482 | 0.84 | CHRM3 (0.62) | CHRNA7BCHEACHECHRM3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585458-B1 | Alkaloid aminoester derivatives and medicinal compositions thereof | CHIESI FARMA SPA (IT) | 2015-01-07 | — | — | EP | disclosed |
| US-8563577-B2 | Alkaloid aminoester derivatives and medicinal composition thereof | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-10-22 | — | — | US | disclosed |
| US-20130196978-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-08-01 | — | — | US | disclosed |
| US-8455646-B2 | Alkaloid aminoester derivatives and medicinal composition thereof | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-06-04 | — | — | US | disclosed |
| EP-2585458-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | Chiesi Farmaceutici S.p.A. (IT) | 2013-05-01 | — | — | EP | disclosed |
| WO-2011160919-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-12-29 | — | — | WO | disclosed |
| US-20110311459-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-12-22 | — | — | US | disclosed |
| US-20100173880-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2010-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130196978-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHRM3, CHRM1, CHRNG | CHRNA7 43/4885BCHE 29/4885ACHE 124/4885 |
| US-20110311459-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHRM3, CHRM5, CHRM2 | CHRNA7 15/4885BCHE 22/4885ACHE 9/4885 |
| US-20100173880-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHRM3, CHRM1, CHRNG | CHRNA7 43/4885BCHE 29/4885ACHE 124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.