Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 11/20 | 0.39 |
| ▸ | ESR1 | P03372 | 6/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | QDPR | P09417 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.33 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15778154 | 0.85 | PANK3 (0.41) | ESR2ESR1CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL26343596 | 0.81 | SLC9A1 (0.43) | ESR2CYP2C9PANK3 | |
| SCHEMBL18640642 | 0.81 | HTR2A (0.35) | ESR2ESR1CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL20256636 | 0.81 | HTR1D (0.39) | ESR2ESR1CYP3A4CYP2C9PANK3 | |
| SCHEMBL16954480 | 0.78 | ESR2 (0.40) | ESR2ESR1CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL3908016 | 0.78 | HTR1D (0.40) | ESR2ESR1CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL16957755 | 0.77 | ESR2 (0.39) | ESR2ESR1CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL16958038 | 0.77 | ESR2 (0.39) | ESR2ESR1CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL16960653 | 0.77 | ESR2 (0.39) | ESR2ESR1CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL16956080 | 0.77 | SLC5A2 (0.46) | ESR2ESR1CYP3A4CYP2C9CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017046739-A1 | IMIDAZOLIDINONE DERIVATIVES AS INHIBITORS OF PERK | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-03-23 | — | — | WO | disclosed |
| WO-2017046739-A1 | IMIDAZOLIDINONE DERIVATIVES AS INHIBITORS OF PERK | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-03-23 | — | — | WO | disclosed |
| EP-2900645-A1 | 3-PHENYLISOXAZOLIN DERIVATIVES WITH HERBICIDAL ACTION | Bayer CropScience AG (DE) | 2015-08-05 | — | — | EP | disclosed |