Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SERPINE1 | P05121 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | POLQ | O75417 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1697043 | 0.85 | MEN1 (0.47) | MEN1KMT2AMAPTLMNASIRT6 | |
| SCHEMBL10226318 | 0.85 | MEN1 (0.49) | MEN1KMT2AMAPTLMNASIRT6 | |
| SCHEMBL40327 | 0.84 | KMT2A (0.53) | MEN1KMT2AMAPTLMNAL3MBTL1 | |
| SCHEMBL1696908 | 0.84 | SERPINE1 (0.43) | MEN1KMT2AMAPTLMNASIRT6 | |
| SCHEMBL45060 | 0.80 | SERPINE1 (0.46) | MEN1KMT2AMAPTLMNASIRT6 | |
| SCHEMBL10225103 | 0.78 | USP30 (0.49) | MEN1KMT2AMAPTLMNASIRT6 | |
| SCHEMBL45810 | 0.78 | SERPINE1 (0.46) | MEN1KMT2AMAPTLMNASIRT6 | |
| SCHEMBL45214 | 0.77 | SERPINE1 (0.47) | MEN1KMT2AMAPTLMNASIRT6 | |
| SCHEMBL15432997 | 0.76 | SIRT6 (0.50) | MEN1KMT2AMAPTLMNASIRT6 | |
| SCHEMBL16691234 | 0.75 | SERPINE1 (0.44) | MEN1KMT2AMAPTLMNASIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590655-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012006473-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |