Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 16/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16894277 | 0.88 | TRPA1 (0.46) | TRPA1 | |
| SCHEMBL16965157 | 0.85 | TRPA1 (0.55) | TRPA1FAAH | |
| SCHEMBL16894232 | 0.81 | TRPA1 (0.50) | TRPA1KDM1AHDAC1 | |
| SCHEMBL16894224 | 0.81 | TRPA1 (0.52) | TRPA1FAAHKDM1AHDAC1 | |
| SCHEMBL16894235 | 0.80 | TRPA1 (0.65) | TRPA1 | |
| SCHEMBL16894191 | 0.79 | TRPA1 (0.47) | TRPA1KDM1AHDAC1 | |
| SCHEMBL16894186 | 0.78 | TRPA1 (0.49) | TRPA1FAAHKDM1AHDAC1 | |
| SCHEMBL19917757 | 0.78 | TRPA1 (0.54) | TRPA1 | |
| SCHEMBL16965653 | 0.77 | KMT2A (0.40) | FAAH | |
| SCHEMBL16894153 | 0.77 | TRPA1 (0.67) | TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2015-08-05 | — | — | EP | disclosed |