Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 15/20 | 0.75 |
| ▸ | INSR | P06213 | 13/20 | 0.75 |
| ▸ | MET | P08581 | 4/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbamic Acid SCHEMBL16966128 | 0.99 | ALK (0.74) | ALKINSRMETSYK | |
| SCHEMBL16965912 | 0.93 | ALK (0.73) | ALKINSRMETSYK | |
| SCHEMBL2943941 | 0.88 | ALK (0.69) | ALKINSRMET | |
| SCHEMBL2061910 | 0.88 | ALK (0.79) | ALKINSRSYK | |
| SCHEMBL2061914 | 0.88 | ALK (0.79) | ALKINSRSYK | |
| SCHEMBL885641 | 0.86 | ALK (0.77) | ALKINSRMETSYK | |
| SCHEMBL885642 | 0.86 | ALK (0.77) | ALKINSRMETSYK | |
| SCHEMBL885640 | 0.86 | ALK (0.77) | ALKINSRMETSYK | |
| SCHEMBL2062352 | 0.86 | ALK (1.00) | ALKINSRMET | |
| SCHEMBL886805 | 0.84 | ALK (0.80) | ALKINSRMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2684874-B1 | Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and C-met inhibitors | CEPHALON INC (US) | 2017-05-17 | — | — | EP | claimed |
| EP-2222647-B1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2015-08-05 | — | — | EP | claimed |