Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 13/20 | 0.69 |
| ▸ | INSR | P06213 | 11/20 | 0.69 |
| ▸ | MET | P08581 | 4/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.47 |
| ▸ | MERTK | Q12866 | 1/20 | 0.47 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.47 |
| ▸ | STK17B | O94768 | 2/20 | 0.46 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2942670 | 0.89 | ALK (0.84) | ALKINSRMET | |
| Carbamic Acid SCHEMBL16965950 | 0.88 | ALK (0.75) | ALKINSRMET | |
| Carbamic Acid SCHEMBL16966128 | 0.87 | ALK (0.74) | ALKINSRMET | |
| SCHEMBL16965912 | 0.86 | ALK (0.73) | ALKINSRMET | |
| SCHEMBL886806 | 0.86 | ALK (0.80) | ALKINSRMETSTK17BSTK17A | |
| SCHEMBL886805 | 0.86 | ALK (0.80) | ALKINSRMETSTK17BSTK17A | |
| SCHEMBL2938942 | 0.86 | ALK (0.80) | ALKINSRMETSTK17BSTK17A | |
| SCHEMBL886804 | 0.86 | ALK (0.80) | ALKINSRMETSTK17BSTK17A | |
| SCHEMBL2061858 | 0.82 | ALK (0.62) | ALKINSRMET | |
| SCHEMBL2062352 | 0.82 | ALK (1.00) | ALKINSRMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |