Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 9/20 | 0.52 |
| ▸ | MET | P08581 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 10/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 10/20 | 0.51 |
| ▸ | INSR | P06213 | 7/20 | 0.48 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL884722 | 0.89 | KDR (0.66) | ALKMETKDRAURKBINSR | |
| SCHEMBL18832758 | 0.82 | ALK (0.49) | ALKMETKDRAURKBINSR | |
| SCHEMBL16966140 | 0.82 | ALK (0.49) | ALKMETKDRAURKBINSR | |
| SCHEMBL16966200 | 0.79 | ALK (0.52) | ALKMETKDRAURKBINSR | |
| SCHEMBL16966016 | 0.78 | ALK (0.63) | ALKMETINSR | |
| SCHEMBL16966156 | 0.78 | ALK (0.53) | ALKMETKDRAURKBINSR | |
| SCHEMBL16965941 | 0.78 | ALK (0.57) | ALKMETKDRAURKBINSR | |
| SCHEMBL16966004 | 0.78 | ALK (0.47) | ALKMETKDRAURKBINSR | |
| SCHEMBL16966262 | 0.78 | INSR (0.56) | ALKMETKDRAURKBINSR | |
| SCHEMBL16966099 | 0.77 | ALK (0.61) | ALKKDRAURKBINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2684874-B1 | Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and C-met inhibitors | CEPHALON INC (US) | 2017-05-17 | — | — | EP | claimed |
| EP-2222647-B1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2015-08-05 | — | — | EP | claimed |