Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.41 |
| ▸ | KDM1A | O60341 | 11/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16966477 | 0.89 | AURKA (0.51) | AURKAPDPK1AURKBKDM1ACYP11B1 | |
| SCHEMBL12119839 | 0.89 | AURKA (0.54) | AURKAPDPK1AURKBEGLN2 | |
| SCHEMBL16966439 | 0.89 | AURKA (0.38) | AURKAPDPK1AURKBPIK3CGROCK1 | |
| SCHEMBL16966441 | 0.86 | KDM1A (0.45) | AURKAPDPK1AURKBKDM1ACYP11B1 | |
| SCHEMBL16966461 | 0.84 | PDPK1 (0.46) | AURKAPDPK1AURKBKDM1ACYP11B1 | |
| SCHEMBL16966467 | 0.84 | AURKA (0.36) | AURKAPDPK1AURKBKDM1A | |
| SCHEMBL1318659 | 0.83 | AURKA (0.48) | AURKAPDPK1AURKBKDM1ACYP11B1 | |
| SCHEMBL12119819 | 0.78 | AURKA (0.67) | AURKAPDPK1AURKBEGLN2 | |
| SCHEMBL1319853 | 0.78 | AURKA (0.52) | AURKAPDPK1AURKBKDM1ACYP11B1 | |
| SCHEMBL16966520 | 0.78 | PDPK1 (0.57) | AURKAPDPK1AURKBPIK3CGROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362775-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-08-05 | — | — | EP | disclosed |