Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 11/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 4/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | TYK2 | P29597 | 3/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1319853 | 0.91 | AURKA (0.52) | KDM1ACYP11B1CYP11B2AURKAPDPK1 | |
| SCHEMBL12119796 | 0.89 | AURKA (0.54) | KDM1AAURKAPDPK1AURKBSYK | |
| SCHEMBL3131514 | 0.89 | CCNC (0.40) | KDM1AAURKAPDPK1AURKBJAK2 | |
| SCHEMBL3121213 | 0.88 | PDPK1 (0.53) | KDM1ACYP11B1CYP11B2AURKAPDPK1 | |
| SCHEMBL16966526 | 0.88 | PDPK1 (0.53) | KDM1ACYP11B1CYP11B2AURKAPDPK1 | |
| SCHEMBL16966468 | 0.86 | AURKA (0.41) | KDM1ACYP11B1CYP11B2AURKAPDPK1 | |
| SCHEMBL16966461 | 0.85 | PDPK1 (0.46) | KDM1ACYP11B1CYP11B2AURKAPDPK1 | |
| SCHEMBL1320953 | 0.85 | KDM1A (0.52) | KDM1ACYP11B1CYP11B2 | |
| SCHEMBL1317620 | 0.83 | CYP11B1 (0.41) | KDM1ACYP11B1CYP11B2AURKAPDPK1 | |
| SCHEMBL13354810 | 0.78 | AURKA (0.58) | AURKAPDPK1AURKBSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362775-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-08-05 | — | — | EP | disclosed |