Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 19/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 14/20 | 0.39 |
| ▸ | AURKA | O14965 | 10/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16966488 | 0.86 | PDPK1 (0.43) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL16966490 | 0.84 | PDPK1 (0.53) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL1318241 | 0.84 | PDPK1 (0.52) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL1318829 | 0.83 | PDPK1 (0.41) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL1318103 | 0.82 | PDPK1 (0.47) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL1317180 | 0.79 | PDPK1 (0.56) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL1318982 | 0.77 | PDPK1 (0.59) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL1317910 | 0.77 | PDPK1 (0.48) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL1320558 | 0.77 | PDPK1 (0.58) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL1319651 | 0.75 | PDPK1 (0.47) | PDPK1AURKBAURKAROCK1PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362775-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-08-05 | — | — | EP | claimed |