Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 20/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 15/20 | 0.53 |
| ▸ | AURKA | O14965 | 11/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.53 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.53 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16966510 | 0.89 | PDPK1 (0.67) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL16966555 | 0.85 | PDPK1 (0.54) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL16966499 | 0.84 | PDPK1 (0.39) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL1317277 | 0.82 | PDPK1 (0.57) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL1317720 | 0.79 | PDPK1 (0.74) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL1318898 | 0.77 | PDPK1 (0.79) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL1319884 | 0.75 | PDPK1 (0.80) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL1317753 | 0.75 | PDPK1 (0.67) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL1318184 | 0.75 | PDPK1 (0.60) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL16966474 | 0.75 | PDPK1 (0.60) | PDPK1AURKBAURKAROCK1PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362775-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-08-05 | — | — | EP | claimed |