Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.39 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 2/20 | 0.38 |
| ▸ | TMPRSS11D | O60235 | 1/20 | 0.38 |
| ▸ | CTRL | P40313 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16910578 | 1.00 | SMN1; SMN2 (0.41) | SMN1; SMN2LMNAALDH1A1ATMPSMB10 | |
| SCHEMBL15571602 | 0.92 | PSMB10 (0.49) | PSMB10PSMB2PSMB5TMPRSS11DCTRL | |
| SCHEMBL16970543 | 0.92 | PSMB10 (0.49) | PSMB10PSMB2PSMB5TMPRSS11DCTRL | |
| SCHEMBL16970533 | 0.91 | PSMB10 (0.48) | PSMB10PSMB2PSMB5TMPRSS11DCTRL | |
| SCHEMBL16910569 | 0.91 | PSMB10 (0.48) | PSMB10PSMB2PSMB5TMPRSS11DCTRL | |
| SCHEMBL16910580 | 0.91 | PSMB10 (0.50) | PSMB10PSMB2PSMB5TMPRSS11DCTRL | |
| SCHEMBL16970553 | 0.89 | PSMB5 (0.52) | PSMB10PSMB2PSMB5MMP12TMPRSS11D | |
| SCHEMBL15569322 | 0.88 | TMPRSS11D (0.51) | ALDH1A1PSMB10PSMB2PSMB5MMP12 | |
| SCHEMBL16910561 | 0.88 | PSMB5 (0.53) | PSMB10PSMB2PSMB5MMP12TMPRSS11D | |
| SCHEMBL16970522 | 0.88 | TMPRSS11D (0.51) | ALDH1A1PSMB10PSMB2PSMB5MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150218212-A1 | FLUORINATED EPOXYKETONE-BASED TETRAPEPTIDE COMPOUNDS AND USES THEREOF AS PROTEASOME INHIBITORS | FLUORINOV PHARMA INC. (CA) | 2015-08-06 | — | — | US | disclosed |
| US-20150218212-A1 | FLUORINATED EPOXYKETONE-BASED TETRAPEPTIDE COMPOUNDS AND USES THEREOF AS PROTEASOME INHIBITORS | FLUORINOV PHARMA INC. (CA) | 2015-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150218212-A1 | FLUORINATED EPOXYKETONE-BASED TETRAPEPTIDE COMPOUNDS AND USES THEREOF AS PROTEASOME INHIBITORS | PSMA1, PSMB1, PSMB11 | SMN1; SMN2 1583/4885LMNA 2389/4885ALDH1A1 3449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.