Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 20/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 9/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1945882 | 0.81 | ADORA2B (0.69) | ADORA2BADORA3ADORA1ADORA2A | |
| SCHEMBL243703 | 0.76 | ADORA2B (0.68) | ADORA2BADORA3ADORA1ADORA2A | |
| SCHEMBL1697143 | 0.75 | ADORA2B (0.70) | ADORA2BADORA3ADORA1ADORA2A | |
| SCHEMBL1948494 | 0.73 | ADORA2B (1.00) | ADORA2BADORA3ADORA1ADORA2A | |
| SCHEMBL31060455 | 0.72 | ADORA2B (1.00) | ADORA2BADORA3ADORA1ADORA2A | |
| SCHEMBL1945881 | 0.72 | ADORA2B (0.84) | ADORA2BADORA3ADORA1ADORA2A | |
| SCHEMBL1944981 | 0.72 | ADORA2B (1.00) | ADORA2BADORA3ADORA1ADORA2A | |
| SCHEMBL243045 | 0.71 | ADORA2B (1.00) | ADORA2BADORA3ADORA1ADORA2A | |
| SCHEMBL244428 | 0.70 | ADORA2B (0.74) | ADORA2BADORA3ADORA1ADORA2A | |
| SCHEMBL1943368 | 0.70 | ADORA2B (0.55) | ADORA2BADORA3ADORA1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595630-A1 | USE OF A2B ADENOSINE RECEPTOR ANTAGONISTS FOR TREATING PULMONARY HYPERTENSION | Gilead Sciences, Inc. (US) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012003220-A1 | USE OF A2B ADENOSINE RECEPTOR ANTAGONISTS FOR TREATING PULMONARY HYPERTENSION | GILEAD SCIENCES, INC. (US) | 2012-01-05 | — | — | WO | disclosed |