⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27735033 | 0.84 | — | — | |
| Hydrochloric Acid SCHEMBL28634019 | 0.82 | KDM4E (0.46) | — | |
| SCHEMBL4065140 | 0.80 | KDM4E (0.52) | — | |
| SCHEMBL48851 | 0.78 | — | — | |
| SCHEMBL4065142 | 0.78 | KDM4E (0.50) | — | |
| Fluoride SCHEMBL27856600 | 0.76 | KDM4E (0.48) | — | |
| SCHEMBL19143605 | 0.76 | — | — | |
| SCHEMBL27217288 | 0.76 | — | — | |
| SCHEMBL9499461 | 0.76 | KDM4E (0.69) | — | |
| SCHEMBL9070404 | 0.76 | L3MBTL1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170305954-A1 | SYNTHESIS OF 2', 3'-DIDEOXYNUCLEOSIDES FOR AUTOMATED DNA SYNTHESIS AND PYROPHOSPHOROLYSIS ACTIVATED POLYMERIZATION | Life Technologies Corporation (US) | 2017-10-26 | — | — | US | disclosed |
| US-9732112-B2 | Synthesis of 2′,3′-dideoxynucleosides for automated DNA synthesis and pyrophosphorolysis activated polymerization | Life Technologies Corporation (US) | 2017-08-15 | — | — | US | disclosed |
| US-20160108079-A1 | Synthesis Of 2',3'-Dideoxynucleosides For Automated DNA Synthesis And Pyrophosphorolysis Activated Polymerization | Life Technologies Corporation | 2016-04-21 | — | — | US | disclosed |
| US-9228227-B2 | Synthesis of 2′, 3′-dideoxynucleosides for automated DNA synthesis and pyrophosphorolysis activated polymerization | Life Technologies Corporation (US) | 2016-01-05 | — | — | US | disclosed |
| EP-2576577-B1 | SYNTHESIS OF 2', 3'-DIDEOXYNUCLEOSIDES FOR AUTOMATED DNA SYNTHESIS AND PYROPHOSPHOROLYSIS ACTIVATED POLYMERIZATION | LIFE TECHNOLOGIES CORP (US) | 2015-03-18 | — | — | EP | disclosed |
| US-20150045547-A1 | Synthesis Of 2' , 3' -Dideoxynucleosides For Automated DNA Synthesis And Pyrophosphorolysis Activated Polymerization | Life Technologies Corporation (US) | 2015-02-12 | — | — | US | disclosed |
| US-8658776-B2 | Synthesis of 2′,3′-dideoxynucleosides for automated DNA synthesis and pyrophosphorolysis activated polymerization | Life Technologies Corporation (US) | 2014-02-25 | — | — | US | disclosed |
| EP-2576577-A2 | SYNTHESIS OF 2', 3'-DIDEOXYNUCLEOSIDES FOR AUTOMATED DNA SYNTHESIS AND PYROPHOSPHOROLYSIS ACTIVATED POLYMERIZATION | Life Technologies Corporation (US) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011150277-A2 | SYNTHESIS OF 2', 3'-DIDEOXYNUCLEOSIDES FOR AUTOMATED DNA SYNTHESIS AND PYROPHOSPHOROLYSIS ACTIVATED POLYMERIZATION | Life Technologies Corporation (US) | 2011-12-01 | — | — | WO | disclosed |
| US-20110294122-A1 | Synthesis of 2', 3'-Dideoxynucleosides for Automated DNA Synthesis and Pyrophosphorolysis Activated Polymerization | Life Technologies Corporation (US) | 2011-12-01 | — | — | US | disclosed |