Known targets — ChEMBL curated mechanism
CACNA1BGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BMAOBSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Ralfinamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A known ✓ | Q15858 | 2/20 | 0.91 |
| ▸ | MAOB known ✓ | P27338 | 6/20 | 0.62 |
| ▸ | SCN3A known ✓ | Q9NY46 | 2/20 | 0.60 |
| ▸ | MAOA | P21397 | 1/20 | 0.62 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.53 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.53 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ralfinamide SCHEMBL1697241 | 1.00 | SCN9A (0.91) | SCN9AMAOBMAOASCN3APARP15 | |
| Ralfinamide SCHEMBL1697234 | 1.00 | SCN9A (0.91) | SCN9AMAOBMAOASCN3APARP15 | |
| Ralfinamide SCHEMBL29379049 | 0.96 | SCN9A (1.00) | SCN9AMAOBMAOASCN3APARP15 | |
| Ralfinamide SCHEMBL67328 | 0.96 | SCN9A (1.00) | SCN9AMAOBMAOASCN3APARP15 | |
| Ralfinamide SCHEMBL67329 | 0.96 | SCN9A (1.00) | SCN9AMAOBMAOASCN3APARP15 | |
| Ralfinamide SCHEMBL962699 | 0.96 | SCN9A (1.00) | SCN9AMAOBMAOASCN3APARP15 | |
| Ralfinamide SCHEMBL1697253 | 0.94 | SCN9A (0.98) | SCN9AMAOBMAOASCN3APARP15 | |
| Ralfinamide SCHEMBL1697252 | 0.94 | SCN9A (0.98) | SCN9AMAOBMAOASCN3APARP15 | |
| SCHEMBL8638247 | 0.90 | SCN9A (0.74) | SCN9AMAOBMAOASCN3AHRH3 | |
| SCHEMBL963787 | 0.88 | SCN9A (0.85) | SCN9AMAOBMAOASCN3APARP15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE40259-E1 | side effects reduction; compounds active on the central nervous system; chronic and neuropathic pain, anti-epileptic, anti-Parkinson, neuroprotective, antidepressant, antispastic and hypnotic agents; 2-[4-(3-fluorobenzyloxy)benzylamino]-2-methylpropanamide | NEWRON PHARMACEUTICALS, S.P.A. (IT) | 2008-04-22 | — | — | US | claimed |
| EP-3257842-B1 | THERAPEUTIC USE OF 2-[4-(3- OR 2-FLUOROBENZYLOXY)BENZYLAMINO]PROPANAMIDES WITH HIGH PURITY DEGREE | NEWRON PHARM SPA (IT) | 2020-11-18 | — | — | EP | disclosed |
| CN-104523668-B | High-purity 2- [4- (3-or 2-fluorobenzyloxy) benzylamino ] propanamides and use thereof | 纽朗制药有限公司 | 2020-06-09 | — | — | CN | disclosed |
| US-9856207-B2 | Process for the production of ralfinamide salts substantially free from impurities having genotoxic effects | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2018-01-02 | — | — | US | disclosed |
| EP-3257842-A1 | PROCESS FOR THE PRODUCTION OF 2-[4-(3- OR 2-FLUOROBENZYLOXY)BENZYLAMINO]PROPANAMIDES WITH HIGH PURITY DEGREE | Newron Pharmaceuticals S.p.A. (IT) | 2017-12-20 | — | — | EP | disclosed |
| EP-2229351-B1 | PROCESS FOR THE PRODUCTION OF 2-[4-(3- OR 2-FLUOROBENZYLOXY)BENZYLAMINO]PROPANAMIDES WITH HIGH PURITY DEGREE | NEWRON PHARM SPA (IT) | 2017-11-08 | — | — | EP | disclosed |
| US-20170029365-A1 | PROCESS FOR THE PRODUCTION OF RALFINAMIDE SALTS SUBSTANTIALLY FREE FROM IMPURITIES HAVING GENOTOXIC EFFECTS | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2017-02-02 | — | — | US | disclosed |
| US-9505708-B2 | Process for the production of ralfinamide salts substantially free from impurities having genotoxic effects | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2016-11-29 | — | — | US | disclosed |
| EP-2474521-B1 | High purity degree 2-[4-(3- and 2-fluorobenzyloxy)benzylamino]propanamides for use as medicaments and pharmaceutical formulations containing them | NEWRON PHARM SPA (IT) | 2016-08-10 | — | — | EP | disclosed |
| EP-2563355-B1 | Process for the production of ralfinamide methanesulfonate salts or their R-enantiomers | NEWRON PHARM SPA (IT) | 2016-06-08 | — | — | EP | disclosed |
| EP-2229351-A1 | PROCESS FOR THE PRODUCTION OF 2-Ý4-(3- OR 2-FLUOROBENZYLOXY)BENZYLAMINO¨PROPANAMIDES WITH HIGH PURITY DEGREE | Newron Pharmaceuticals S.p.A. (IT) | 2010-09-22 | — | — | EP | disclosed |
| EP-1809271-B9 | USE OF (R)-(HALOBENZYLOXY) BENZYLAMINO-PROPANAMIDES AS SODIUM AND/OR CALCIUM CHANNEL SELECTIVE MODULATORS | NEWRON PHARM SPA (IT) | 2010-09-22 | — | — | EP | disclosed |
| EP-1809271-B1 | USE OF (R)-(HALOBENZYLOXY) BENZYLAMINO-PROPANAMIDES AS SODIUM AND/OR CALCIUM CHANNEL SELECTIVE MODULATORS | NEWRON PHARM SPA (IT) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009074478-A1 | PROCESS FOR THE PRODUCTION OF 2-[4-(3- OR 2-FLUOROBENZYLOXY)BENZYLAMINO]PROPANAMIDES WITH HIGH PURITY DEGREE | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2009-06-18 | — | — | WO | disclosed |
| US-20090156678-A1 | PROCESS FOR THE PRODUCTION OF 2-[4-(3- AND 2-FLUOROBENZYLOXY) BENZYLAMINO] PROPANAMIDES | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2009-06-18 | — | — | US | disclosed |
| EP-2029524-A1 | PROCESS FOR THE PRODUCTION OF 2- [4 - ( 3- AND 2-FLUOROBENZYLOXY) BENZYLAMINO] PROPAN AMIDES | Newron Pharmaceuticals S.p.A. (IT) | 2009-03-04 | — | — | EP | disclosed |
| US-20080096965-A1 | (Halobenzyloxy) Benzylamino-Propanamides as Sodium and/or Calcium Channel Selective Modulators | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2008-04-24 | — | — | US | disclosed |
| WO-2007147491-A1 | PROCESS FOR THE PRODUCTION OF 2- [4 - ( 3- AND 2-FLU0R0BENZYL0XY) BENZYLAMIN0] PROPAN AMIDES | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2007-12-27 | — | — | WO | disclosed |
| EP-1809271-A2 | (HALOBENZYLOXY) BENZYLAMINO-PROPANAMIDES AS SODIUM AND/OR CALCIUM CHANNEL SELECTIVE MODULATORS | Newron Pharmaceuticals S.p.A. (IT) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006027052-A2 | (HALOBENZYLOXY) BENZYLAMINO-PROPANAMIDES AS SODIUM AND/OR CALCIUM CHANNEL SELECTIVE MODULATORS | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2006-03-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156678-A1 | PROCESS FOR THE PRODUCTION OF 2-[4-(3- AND 2-FLUOROBENZYLOXY) BENZYLAMINO] PROPANAMIDES | PTMA, PSMB2, PDGFRA | SCN9A 407/4885MAOB 129/4885SCN3A 272/4885 |
| US-20170029365-A1 | PROCESS FOR THE PRODUCTION OF RALFINAMIDE SALTS SUBSTANTIALLY FREE FROM IMPURITIES HAVING GENOTOXIC EFFECTS | RALA, KRAS, RAP2C | SCN9A 2723/4885MAOB 4062/4885SCN3A 1079/4885 |
| US-20080096965-A1 | (Halobenzyloxy) Benzylamino-Propanamides as Sodium and/or Calcium Channel Selective Modulators | CACNA1E, TRPV1, KCNN2 | SCN9A 111/4885MAOB 1870/4885SCN3A 62/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.