PSMB2

Proteasome Macropain subunit · P49721 · PSMB2 on Sugi Atlas →

43,187 patent compounds predicted against PSMB2, 29,219 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL605949 SCHEMBL605949 0.54 15/20
SCHEMBL607010 SCHEMBL607010 0.56 12/20
SCHEMBL607553 SCHEMBL607553 0.54 12/20
SCHEMBL606932 SCHEMBL606932 0.53 12/20
SCHEMBL608381 SCHEMBL608381 0.53 12/20
SCHEMBL606926 SCHEMBL606926 0.52 12/20
SCHEMBL606344 SCHEMBL606344 0.51 12/20
SCHEMBL606616 SCHEMBL606616 0.51 12/20
SCHEMBL607035 SCHEMBL607035 0.61 11/20
SCHEMBL605158 SCHEMBL605158 0.59 11/20
SCHEMBL606315 SCHEMBL606315 0.59 11/20
SCHEMBL85003 SCHEMBL85003 0.58 11/20
SCHEMBL85066 SCHEMBL85066 0.56 11/20
SCHEMBL464494 SCHEMBL464494 0.56 11/20
SCHEMBL464427 SCHEMBL464427 0.55 11/20
SCHEMBL607972 SCHEMBL607972 0.55 11/20
SCHEMBL607962 SCHEMBL607962 0.54 11/20
SCHEMBL605822 SCHEMBL605822 0.54 11/20
SCHEMBL608362 SCHEMBL608362 0.53 11/20
SCHEMBL605129 SCHEMBL605129 0.52 11/20

Clinical trials — most relevant to PSMB2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Patients With Crohn's Disease PHASE4UNKNOWN
Doxorubicin and Bortezomib in Treating Patients With Liver Cancer PHASE2COMPLETED
A Study of GSK2110183 in Subjects With Proteasome Inhibitor Refractory Multiple Myeloma PHASE2WITHDRAWN
A Study of the Safety and Efficacy of CNTO 328 and Bortezomib to Bortezomib Alone in Patients With Relapsed or Refractory Multiple Myeloma PHASE2COMPLETED
Tamoxifen and Bortezomib to Treat Recurrent Brain Tumors PHASE2COMPLETED
Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes PHASE2UNKNOWN
Trial to Evaluate Efficacy and Safety of Bortezomib in Patients With Severe Autoimmune Encephalitis PHASE2RECRUITING
The Effect of Roxadustat on Renal Oxygenation in Diabetes Nephropathy PHASE2NOT_YET_RECRUITING
A Prevention Trial in Subjects at High Risk for Breast Cancer PHASE2COMPLETED
A Phase 2 Study to Investigate the Clinical Activity of IPI-504 in Patients With Hormone-resistant Prostate Cancer PHASE2COMPLETED
Bortezomib and Docetaxel in Treating Patients With Recurrent or Metastatic Head and Neck Cancer PHASE2COMPLETED
Open-label, Phase II Study of MLN9708 in Patients With Relapsed/Refractory Cutaneous and Peripheral T-cell Lymphomas PHASE2COMPLETED
Relapsed and/or Refractory Non-Hodgkin Lymphoma Study PHASE2WITHDRAWN
Study of Patients With Stage IV Malignant Melanoma Using PS-341 (Bortezomib, Velcade) and Interferon-alpha-2b in Malignant Melanoma PHASE1COMPLETED
PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck PHASE1COMPLETED
Extended Infusion Carfilzomib on a Weekly Schedule in Patients With Advanced Solid Tumors PHASE1COMPLETED
GO-203-2C + Bortezomib For Relapsed Or Refractory MM PHASE1WITHDRAWN
Study of Marizomib With Temozolomide and Radiotherapy in Patients With Newly Diagnosed Brain Cancer PHASE1COMPLETED
Study of Irinotecan and Bortezomib in Children With Recurrent/Refractory Neuroblastoma PHASE1COMPLETED
PS-341 in Treating Patients With Advanced Solid Tumors or Lymphoma PHASE1COMPLETED
Bortezomib, Fluorouracil, and Leucovorin Calcium in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed By Surgery PHASE1COMPLETED
Evaluation of Proteasome as a Marker of Hepatocellular Carcinoma in Cirrhotic Patients Following Curative Treatment nanUNKNOWN
Cardiovascular Complications of Carfilzomib Treatment nanUNKNOWN
Clinical Study of 68Ga-DOTA-BLP PET Imaging in Noninvasive Diagnosis of Malignant Tumors nanNOT_YET_RECRUITING
Low Dose Melphalan and Bortezomib for AML and High-Risk MDS nanCOMPLETED
The PREServation of MUScle Function in Critically Ill Patients (PRESMUS) nanUNKNOWN
Impact of O6-methylguanine-DNA Methyltransferase (MGMT) Promoter Methylation and MGMT Expression on Dacarbazine Treated Sarcoma Patients (MGMT) nanUNKNOWN
Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive Tract nanUNKNOWN
The Pathophysiology of Bortezomib Induced Peripheral Neuropathy nanUNKNOWN
Establishment of Human Cellular Disease Models for Wilson Disease nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a PSMB2 binder may also engage these)

ProteinNameSimilarity
Q5E9K0 1.000 Q5E9K0 →
P40307 1.000 P40307 →
Q9R1P3 1.000 Q9R1P3 →
O23714 0.987 O23714 →
Q9LST6 0.984 Q9LST6 →
O24633 0.984 O24633 →
Q9P6U7 0.981 Q9P6U7 →
P28024 0.979 P28024 →
Q3T108 0.975 Q3T108 →
P34067 0.973 P34067 →
P99026 0.971 P99026 →
PSMB1 Proteasome component C5 0.968 landscape →
PSMB4 Proteasome subunit beta type-4 0.967 landscape →
Q9IB83 0.966 Q9IB83 →
P18421 0.964 P18421 →
Q2TBX6 0.963 Q2TBX6 →
Q6DRF3 0.963 Q6DRF3 →
Q9IB84 0.963 Q9IB84 →
O09061 0.957 O09061 →
P22141 0.953 P22141 →
O48551 0.952 O48551 →
Q7DLR9 0.952 Q7DLR9 →
O81147 0.950 O81147 →
Q9XG77 0.949 Q9XG77 →
Q09720 0.948 Q09720 →
Q9UQY2 0.948 Q9UQY2 →
O81146 0.947 O81146 →
P23724 0.946 P23724 →
Q9LSU3 0.945 Q9LSU3 →
P40304 0.945 P40304 →