Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 9/20 | 0.48 |
| ▸ | PDE1B | Q01064 | 9/20 | 0.48 |
| ▸ | PDE1C | Q14123 | 9/20 | 0.48 |
| ▸ | PDE9A | O76083 | 5/20 | 0.48 |
| ▸ | PDE5A | O76074 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | GUSB | P08236 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | PNP | P00491 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PDE6D | O43924 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6365530 | 0.94 | PDE1A (0.46) | PDE1APDE1BPDE1CPDE9APDE5A | |
| SCHEMBL6372442 | 0.88 | PDE1A (0.51) | PDE1APDE1BPDE1CPDE9APDE5A | |
| SCHEMBL3494602 | 0.84 | AR (0.48) | PDE1APDE1BPDE1CPDE9APDE5A | |
| SCHEMBL6368321 | 0.84 | PDE9A (0.59) | PDE1APDE1BPDE1CPDE9APDE5A | |
| SCHEMBL6365996 | 0.83 | PDE1A (0.57) | PDE1APDE1BPDE1CPDE9APDE5A | |
| SCHEMBL1028 | 0.83 | PDE5A (0.68) | PDE1APDE1BPDE1CPDE9APDE5A | |
| SCHEMBL7360299 | 0.81 | PDE5A (0.39) | PDE1APDE1BPDE1CPDE9APDE5A | |
| SCHEMBL7085453 | 0.80 | PDE5A (0.36) | PDE1APDE1BPDE1CPDE9APDE5A | |
| SCHEMBL6374090 | 0.80 | PDE1A (0.48) | PDE1APDE1BPDE1CPDE9APDE5A | |
| SCHEMBL8244420 | 0.78 | PDE5A (0.45) | PDE1APDE1BPDE1CPDE9APDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3099689-A1 | PYRAZOLOPYRIMIDINONES FOR THE TREATMENT OF IMPOTENCE AND PROCESS FOR THE PREPARATION THEREOF | Council of Scientific and Industrial Research (IN) | 2016-12-07 | — | — | EP | disclosed |
| WO-2015114647-A1 | PYRAZOLOPYRIMIDINONES FOR THE TREATMENT OF IMPOTENCE AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2015-08-06 | — | — | WO | disclosed |