Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 12/20 | 0.39 |
| ▸ | PDE1A | P54750 | 6/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 6/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 6/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PNP | P00491 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PDE6C | P51160 | 3/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.31 |
| ▸ | PDE9A | O76083 | 2/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.31 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.31 |
| ▸ | PDE6D | O43924 | 1/20 | 0.31 |
| ▸ | PDE8A | O60658 | 1/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16972452 | 0.81 | PDE1A (0.48) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL6365530 | 0.76 | PDE1A (0.46) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL1028 | 0.74 | PDE5A (0.68) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL16972445 | 0.73 | CCNB2 (0.41) | KMT2AALDH1A1KDM4E | |
| SCHEMBL7085453 | 0.72 | PDE5A (0.36) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL7019558 | 0.72 | PARP1 (0.41) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL3671939 | 0.72 | PDE5A (0.55) | PDE5APDE1APDE1BPDE1CPDE6C | |
| SCHEMBL7431615 | 0.72 | PDE5A (0.48) | PDE5APDE1APDE1BPDE1CPDE6C | |
| SCHEMBL7360293 | 0.71 | ALDH1A1 (0.39) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL8237549 | 0.70 | CCNE2 (0.35) | PDE5APDE1APDE1BPDE1CKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001003644-A9 | PYRAZOLOPYRIMIDINONE DERIVATIVES CONJUGATED TO THIOPHENE MOIETIES OR BENZO [FUSED] 5-MEMBERED HETEROCYCLES FOR ERECTILE DYSFUNCTION | PICOWER INST MED RES (US) | 2001-11-29 | — | — | WO | disclosed |