Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9182227 | 0.86 | PTPN1 (0.47) | CA1CA2TSHRPTPN1CHRM3 | |
| SCHEMBL43992 | 0.86 | — | — | |
| Acetic Acid SCHEMBL5156006 | 0.84 | PTPN1 (0.49) | CA1CA2TSHRPTPN1CHRM3 | |
| Acrylic Acid SCHEMBL305444 | 0.78 | PTPN1 (0.48) | TSHRPTPN1CHRM3ALDH1A1KDM4E | |
| Terephthalic Acid SCHEMBL18394717 | 0.78 | TSHR (0.70) | CA1CA2TSHRTP53ALDH1A1 | |
| Terephthalic Acid SCHEMBL4349174 | 0.78 | TSHR (0.70) | CA1CA2TSHRTP53ALDH1A1 | |
| SCHEMBL27555709 | 0.78 | TSHR (0.70) | CA1CA2TSHRTP53ALDH1A1 | |
| SCHEMBL63466 | 0.78 | TSHR (0.70) | CA1CA2TSHRTP53ALDH1A1 | |
| Terephthalic Acid SCHEMBL8811649 | 0.78 | TSHR (0.70) | CA1CA2TSHRTP53ALDH1A1 | |
| SCHEMBL11668494 | 0.76 | TSHR (0.67) | CA1CA2TSHRTP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486600-A2 | METHOD FOR MANUFACTURING MULTILAYER FILMS AND SOLAR PANEL BACKSHEETS FORMED THEREOF | E. I. du Pont de Nemours and Company (US) | 2012-08-15 | — | — | EP | disclosed |
| US-20110247681-A1 | METHOD FOR MANUFACTURING MULTILAYER FILMS AND SOLAR PANEL BACKSHEETS FORMED THEREOF | E. I. DU PONT DE NEMOURS AND COMPANY (DE) | 2011-10-13 | — | — | US | disclosed |
| WO-2011044417-A2 | METHOD FOR MANUFACTURING MULTILAYER FILMS AND SOLAR PANEL BACKSHEETS FORMED THEREOF | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-04-14 | — | — | WO | disclosed |