Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.51 |
| ▸ | MEN1 | O00255 | 6/20 | 0.51 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14893183 | 0.89 | POLB (0.69) | POLBPTGS2KMT2AMEN1NLRP3 | |
| SCHEMBL1780002 | 0.89 | PTGS2 (0.68) | POLBPTGS2KMT2AMEN1NLRP3 | |
| SCHEMBL7254761 | 0.88 | POLB (0.54) | POLBPTGS2KMT2AMEN1NLRP3 | |
| SCHEMBL23928572 | 0.87 | PTGS2 (0.61) | POLBPTGS2KMT2AMEN1NLRP3 | |
| SCHEMBL16973982 | 0.83 | PTGS2 (0.58) | POLBPTGS2KMT2AMEN1NLRP3 | |
| SCHEMBL11539970 | 0.82 | PTGS2 (0.68) | POLBPTGS2KMT2AMEN1NLRP3 | |
| SCHEMBL11254624 | 0.81 | PTGS2 (0.80) | POLBPTGS2KMT2AMEN1NLRP3 | |
| SCHEMBL16973964 | 0.81 | NR1H4 (0.55) | POLBKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL23928639 | 0.80 | PTGS2 (0.74) | POLBPTGS2KMT2AMEN1NLRP3 | |
| SCHEMBL16973972 | 0.76 | POLB (0.75) | POLBPTGS2KMT2AMEN1NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015116856-A2 | FARNESOID X RECEPTOR ANTAGONISTS | CITY OF HOPE (US) | 2015-08-06 | — | — | WO | disclosed |