Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 11/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | LATS1 | O95835 | 1/20 | 0.32 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.32 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.32 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.32 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.32 |
| ▸ | ATP1A2 | P50993 | 1/20 | 0.32 |
| ▸ | ATP1B3 | P54709 | 1/20 | 0.32 |
| ▸ | FXYD2 | P54710 | 1/20 | 0.32 |
| ▸ | ATP1A4 | Q13733 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16974839 | 0.90 | KMT2A (0.39) | KMT2AHSD17B10MAPKAPK2GAAGPR55 | |
| SCHEMBL16974914 | 0.86 | GAA (0.38) | KMT2AHSD17B10MAPKAPK2GAAGPR55 | |
| SCHEMBL16974853 | 0.86 | GPR55 (0.43) | KMT2AGPR55NOX1 | |
| SCHEMBL16974900 | 0.85 | GAA (0.38) | KMT2AGAAHDAC4HDAC1HDAC6 | |
| SCHEMBL8582685 | 0.83 | NOX1 (0.40) | NOX1 | |
| SCHEMBL16974885 | 0.81 | GAA (0.38) | KMT2AGAAHDAC4HDAC1HDAC6 | |
| SCHEMBL8585922 | 0.81 | NOX1 (0.38) | NOX1 | |
| SCHEMBL8586570 | 0.79 | NOX1 (0.36) | HSD17B10NOX1 | |
| SCHEMBL16974879 | 0.78 | GAA (0.38) | KMT2AGAANOX1HDAC1HDAC6 | |
| SCHEMBL8585872 | 0.77 | NOX1 (0.44) | MAPTNOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3099304-A1 | NOVEL THERAPEUTICS FOR THE TREATMENT OF GLAUCOMA | Mayo Foundation for Medical Education and Research (US) | 2016-12-07 | — | — | EP | disclosed |
| WO-2015117024-A1 | NOVEL THERAPEUTICS FOR THE TREATMENT OF GLAUCOMA | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2015-08-06 | — | — | WO | disclosed |