Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 9/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 6/20 | 0.33 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | PDE8A | O60658 | 2/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.33 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | PDE9A | O76083 | 1/20 | 0.32 |
| ▸ | LSS | P48449 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13333214 | 0.86 | PDE4A (0.44) | PDE5APDE4APDE2APDE8APDE3B | |
| SCHEMBL16977207 | 0.84 | PDE5A (0.36) | PDE5APDE4APDE2APDE8APDE3B | |
| SCHEMBL12281246 | 0.78 | PDE4A (0.47) | PDE5APDE4APDE2APDE8APDE3B | |
| SCHEMBL15745628 | 0.71 | PDE4A (0.48) | PDE5APDE4APDE2APDE8APDE3B | |
| SCHEMBL12281371 | 0.70 | PDE4A (0.48) | PDE5APDE4APDE2APDE8APDE3B | |
| SCHEMBL798740 | 0.70 | PDE4A (0.59) | PDE5APDE4APDE2APDE8APDE3B | |
| SCHEMBL16977213 | 0.68 | SYK (0.51) | — | |
| SCHEMBL2362682 | 0.65 | PDE4A (0.54) | PDE5APDE4APDE2APDE8APDE3B | |
| SCHEMBL12281182 | 0.64 | PDE4A (0.47) | PDE5APDE4APDE2APDE8APDE3B | |
| SCHEMBL12281180 | 0.61 | PDE4A (0.64) | PDE5APDE4APDE2APDE8APDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358204-B1 | 4,5,7,8-tetrahydro-4-oxo-2H-imidazo[1,2-a]pyrrolo[3,4-e]pyrimidine compounds as PDE1 inhibitors. | INTRA CELLULAR THERAPIES INC (US) | 2015-08-05 | — | — | EP | disclosed |