Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.51 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16977232 | 0.77 | SYK (0.40) | SYK | |
| SCHEMBL16977200 | 0.75 | MDM2 (0.42) | SYK | |
| SCHEMBL13333214 | 0.69 | PDE4A (0.44) | — | |
| SCHEMBL16977208 | 0.68 | PDE5A (0.34) | — | |
| SCHEMBL1353611 | 0.67 | SYK (1.00) | SYK | |
| SCHEMBL2729025 | 0.67 | SYK (0.71) | SYK | |
| SCHEMBL16586508 | 0.64 | TNIK (0.48) | SYK | |
| SCHEMBL15278893 | 0.63 | TNIK (0.52) | SYK | |
| SCHEMBL9105646 | 0.61 | SYK (0.56) | SYK | |
| SCHEMBL18926094 | 0.61 | SYK (0.64) | SYKZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358204-B1 | 4,5,7,8-tetrahydro-4-oxo-2H-imidazo[1,2-a]pyrrolo[3,4-e]pyrimidine compounds as PDE1 inhibitors. | INTRA CELLULAR THERAPIES INC (US) | 2015-08-05 | — | — | EP | disclosed |