SCHEMBL16979809

SCHEMBL16979809

COC(=O)c1ccc(Oc2ccc(C(=O)Oc3ccc(C4(c5ccc(C)cc5)CCC(C)(C)C4)cc3)cc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.46
KMT2A Q03164 7/20 0.43
MEN1 O00255 2/20 0.43
ACR P10323 4/20 0.41
PRSS1 P07477 2/20 0.41
HGFAC Q04756 1/20 0.41
ALDH1A1 P00352 3/20 0.40
MAPT P10636 2/20 0.40
HPGD P15428 2/20 0.40
MMP13 P45452 2/20 0.40
POLB P06746 1/20 0.39
SLC6A2 P23975 1/20 0.39
SLC6A4 P31645 1/20 0.39
SLC6A3 Q01959 1/20 0.39
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
KDM4E B2RXH2 1/20 0.38
MMP2 P08253 1/20 0.38
MMP3 P08254 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16979795 0.93 TDP1 (0.48) TDP1KMT2AMEN1ACRPRSS1
SCHEMBL16979787 0.87 TDP1 (0.40) TDP1KMT2AMEN1ACRPRSS1
SCHEMBL16979800 0.86 TDP1 (0.46) TDP1KMT2AMEN1ACRPRSS1
SCHEMBL16979798 0.85 ESR1 (0.46) TDP1KMT2AMEN1ACRPRSS1
SCHEMBL13030420 0.85 TDP1 (0.49) TDP1KMT2AMEN1ACRPRSS1
SCHEMBL16979799 0.84 TDP1 (0.43) TDP1KMT2AMEN1ACRPRSS1
SCHEMBL16979791 0.83 TDP1 (0.44) TDP1KMT2AMEN1ACRPRSS1
SCHEMBL13030417 0.81 TDP1 (0.69) TDP1KMT2AMEN1ACRPRSS1
SCHEMBL16979808 0.81 ESR1 (0.49) TDP1KMT2AMEN1ACRPRSS1
SCHEMBL13864906 0.81 TDP1 (0.53) TDP1KMT2AMEN1ACRPRSS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9778581-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2017-10-03 US disclosed
US-9665020-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2017-05-30 US disclosed
US-20150277249-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2015-10-01 US disclosed
US-20150220007-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2015-08-06 US disclosed