Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Betamethasone Dipropionate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 7/20 | 0.94 |
| ▸ | PGR | P06401 | 5/20 | 0.94 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.94 |
| ▸ | MAPT | P10636 | 2/20 | 0.94 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.94 |
| ▸ | DRD2 | P14416 | 1/20 | 0.94 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.79 |
| ▸ | USP2 | O75604 | 5/20 | 0.79 |
| ▸ | LMNA | P02545 | 3/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.79 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.79 |
| ▸ | MLNR | O43193 | 1/20 | 0.79 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.79 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.79 |
| ▸ | PPARG | P37231 | 1/20 | 0.79 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.79 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.79 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.76 |
| ▸ | CNR1 | P21554 | 2/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Betamethasone Dipropionate SCHEMBL2403727 | 0.99 | NR3C1 (0.95) | NR3C1PGRNR1I2MAPTADORA3 | |
| Betamethasone Dipropionate SCHEMBL515749 | 0.99 | NR3C1 (0.95) | NR3C1PGRNR1I2MAPTADORA3 | |
| Betamethasone Dipropionate SCHEMBL7520 | 0.99 | NR3C1 (0.95) | NR3C1PGRNR1I2MAPTADORA3 | |
| Betamethasone Dipropionate SCHEMBL4188760 | 0.98 | NR3C1 (0.98) | NR3C1PGRNR1I2MAPTADORA3 | |
| Betamethasone Dipropionate SCHEMBL10013893 | 0.97 | NR3C1 (1.00) | NR3C1PGRNR1I2MAPTADORA3 | |
| Betamethasone Dipropionate SCHEMBL20097870 | 0.97 | NR3C1 (1.00) | NR3C1PGRNR1I2MAPTADORA3 | |
| Betamethasone Dipropionate SCHEMBL9768468 | 0.97 | NR3C1 (1.00) | NR3C1PGRNR1I2MAPTADORA3 | |
| Dexamethasone Dipropionate SCHEMBL43107 | 0.97 | NR3C1 (1.00) | NR3C1PGRNR1I2MAPTADORA3 | |
| Betamethasone Dipropionate SCHEMBL11429865 | 0.97 | NR3C1 (1.00) | NR3C1PGRNR1I2MAPTADORA3 | |
| Betamethasone Dipropionate SCHEMBL13028946 | 0.97 | NR3C1 (1.00) | NR3C1PGRNR1I2MAPTADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3846778-A1 | ORAL FILM COMPOSITIONS AND DOSAGE FORMS HAVING PRECISE ACTIVE DISSOLUTION PROFILES | Aquestive Therapeutics, Inc. (US) | 2021-07-14 | — | — | EP | disclosed |
| CN-103732264-A | In-situ gel forming compositions | CARBYLAN BIOSURGERY INC | 2014-04-16 | — | — | CN | disclosed |
| EP-2575736-A1 | ORAL FILM DOSAGE FORM HAVING PHYSICAL-CHEMICAL IDENTIFIER THEREON | MonoSol Rx, LLC (US) | 2013-04-10 | — | — | EP | disclosed |
| EP-2575735-A1 | ORAL FILM DOSAGE FORM HAVING INDICIA THEREON | MonoSol Rx, LLC (US) | 2013-04-10 | — | — | EP | disclosed |
| EP-2568975-A1 | FILM COMPOSITIONS FOR DELIVERY OF ACTIVES | MonoSol Rx, LLC (US) | 2013-03-20 | — | — | EP | disclosed |
| US-8349297-B2 | Topical formulations | MEDPHARM LIMITED (GB) | 2013-01-08 | — | — | US | disclosed |
| EP-2538913-A1 | DEVICE AND SYSTEM FOR DETERMINING, PREPARING AND ADMINISTERING THERAPEUTICALLY EFFECTIVE DOSES | MonoSol Rx, LLC (US) | 2013-01-02 | — | — | EP | disclosed |
| EP-2533769-A1 | METHOD AND SYSTEM FOR OPTIMIZING FILM PRODUCTION AND MINIMIZING FILM SCRAP | MonoSol Rx, LLC (US) | 2012-12-19 | — | — | EP | disclosed |
| EP-1931310-B1 | Monophasic film-forming composition for topical administration | MEDPHARM LTD (GB) | 2012-06-06 | — | — | EP | disclosed |
| WO-2011150302-A1 | ORAL FILM DOSAGE FORM HAVING INDICIA THEREON | MONOSOL RX, LLC (US) | 2011-12-01 | — | — | WO | disclosed |
| WO-2011150306-A1 | ORAL FILM DOSAGE FORM HAVING PHYSICAL-CHEMICAL IDENTIFIER THEREON | MONOSOI RX, LLC (US) | 2011-12-01 | — | — | WO | disclosed |
| WO-2011143424-A1 | FILM COMPOSITIONS FOR DELIVERY OF ACTIVES | MONOSOL RX, LLC (US) | 2011-11-17 | — | — | WO | disclosed |
| WO-2011106341-A1 | DEVICE AND SYSTEM FOR DETERMINING, PREPARING AND ADMINISTERING THERAPEUTICALLY EFFECTIVE DOSES | MONOSOL RX, LLC (US) | 2011-09-01 | — | — | WO | disclosed |
| WO-2011106342-A1 | USE OF DAMS TO IMPROVE YIELD IN FILM PROCESSING | MONOSOL RX, LLC (US) | 2011-09-01 | — | — | WO | disclosed |
| WO-2011100423-A1 | METHOD AND SYSTEM FOR OPTIMIZING FILM PRODUCTION AND MINIMIZING FILM SCRAP | MONOSOL RX, LLC (US) | 2011-08-18 | — | — | WO | disclosed |
| US-20090191271-A1 | Topical Formulations | MED PHARM LIMITED (GB) | 2009-07-30 | — | — | US | disclosed |
| CN-101304729-A | Oil-in-water-type emulsion for topical application in dermatology | GALDERMA SA (CH) | 2008-11-12 | — | — | CN | disclosed |
| US-20080207570-A1 | Topically applicable oil-in-water emulsions and dermatological applications thereof | L'OREAL (FR) | 2008-08-28 | — | — | US | disclosed |