Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 12/20 | 0.57 |
| ▸ | DGAT1 | O75907 | 6/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | CCKBR | P32239 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18475602 | 0.98 | FOLH1 (0.59) | FOLH1DGAT1 | |
| SCHEMBL19215890 | 0.93 | FOLH1 (0.56) | FOLH1DGAT1CCKBR | |
| SCHEMBL16983571 | 0.88 | CA9 (0.53) | FOLH1CCKBR | |
| SCHEMBL19216011 | 0.85 | FOLH1 (0.51) | FOLH1DGAT1CCKBR | |
| SCHEMBL16983523 | 0.85 | FOLH1 (0.51) | FOLH1DGAT1CCKBR | |
| SCHEMBL18475601 | 0.84 | CA9 (0.49) | FOLH1 | |
| SCHEMBL23900363 | 0.84 | FOLH1 (0.54) | FOLH1DGAT1 | |
| SCHEMBL18475551 | 0.83 | FOLH1 (0.42) | FOLH1DGAT1CCKBR | |
| SCHEMBL18475597 | 0.82 | FOLH1 (0.45) | FOLH1DGAT1CCKBR | |
| SCHEMBL18475519 | 0.82 | FOLH1 (0.50) | FOLH1DGAT1CCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210308269-A1 | Small Molecule Drug Conjugates | EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH (CH) | 2021-10-07 | — | — | US | disclosed |
| US-9884122-B2 | Small molecule drug conjugates | ETH ZURICH (CH) | 2018-02-06 | — | — | US | disclosed |
| US-20170224831-A1 | Small Molecule Drug Conjugates | ETH ZURICH (CH) | 2017-08-10 | — | — | US | disclosed |
| US-20170035892-A1 | Small Molecule Drug Conjugates | ETH ZURICH (CH) | 2017-02-09 | — | — | US | disclosed |
| WO-2015114171-A1 | SMALL MOLECULE DRUG CONJUGATES | EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH (CH) | 2015-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210308269-A1 | Small Molecule Drug Conjugates | CA9, CA12, CA2 | FOLH1 29/4885DGAT1 3653/4885PTPN1 2045/4885 |
| US-20170035892-A1 | Small Molecule Drug Conjugates | CA9, CA11, CA4 | FOLH1 74/4885DGAT1 3127/4885PTPN1 3348/4885 |
| US-20170224831-A1 | Small Molecule Drug Conjugates | CA9, CA12, CA2 | FOLH1 29/4885DGAT1 3653/4885PTPN1 2045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.