Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16984569 | 0.89 | USP30 (0.48) | USP30POLBHDAC4LMNAPARP1 | |
| SCHEMBL16984667 | 0.83 | USP30 (0.57) | USP30POLBEPHX1HDAC4LMNA | |
| SCHEMBL16984593 | 0.83 | PARP1 (0.48) | EPHX1PARP1 | |
| SCHEMBL16973688 | 0.82 | CD38 (0.42) | — | |
| SCHEMBL3504310 | 0.82 | ALDH1A1 (0.55) | POLBEPHX1L3MBTL1ALDH1A1NPC1 | |
| SCHEMBL16973834 | 0.81 | SMYD3 (0.46) | HDAC4 | |
| SCHEMBL19782581 | 0.80 | KMT2A (0.41) | L3MBTL1KMT2A | |
| SCHEMBL16984572 | 0.80 | POLB (0.54) | POLBHDAC4LMNAPARP1MAPT | |
| SCHEMBL24150914 | 0.79 | USP30 (0.55) | USP30POLBEPHX1HDAC4PARP1 | |
| SCHEMBL2957946 | 0.78 | EPHX1 (0.55) | USP30POLBEPHX1HDAC4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015113927-A1 | AMINO-SUBSTITUTED ISOTHIAZOLES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-08-06 | — | — | WO | disclosed |