Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 14/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.53 |
| ▸ | TTK | P33981 | 3/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclopropane SCHEMBL16986946 | 0.78 | JAK1 (0.50) | JAK2 | |
| SCHEMBL3095594 | 0.74 | PIK3CG (0.43) | PIK3CGPIK3CDPIK3CAPIK3CBLRRK2 | |
| SCHEMBL3098937 | 0.70 | PIK3CG (1.00) | PIK3CGPIK3CDTTKPIK3CAPIK3CB | |
| SCHEMBL3090226 | 0.69 | PIK3CG (0.68) | PIK3CGPIK3CDTTKPIK3CA | |
| Cyclopropane SCHEMBL16175606 | 0.68 | TTK (0.75) | PIK3CGPIK3CDTTK | |
| SCHEMBL3081503 | 0.67 | PIK3CG (0.77) | PIK3CGPIK3CDTTKPIK3CAPIK3CB | |
| SCHEMBL3092025 | 0.66 | PIK3CG (0.71) | PIK3CGPIK3CDTTKPIK3CA | |
| SCHEMBL3104880 | 0.66 | PIK3CG (1.00) | PIK3CGPIK3CDPIK3CAPIK3CB | |
| Cyclopropane SCHEMBL16175566 | 0.65 | TTK (0.73) | PIK3CGTTKPIK3CALRRK2JAK2 | |
| SCHEMBL3098870 | 0.65 | PIK3CG (0.74) | PIK3CGPIK3CDTTKPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057158-B1 | TRIAZOLE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LTD (GB) | 2015-08-12 | — | — | EP | claimed |