Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 12/20 | 0.50 |
| ▸ | JAK2 | O60674 | 7/20 | 0.47 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.43 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13031181 | 0.84 | JAK1 (0.70) | JAK1JAK2TYK2JAK3IKBKB | |
| Cyclopropane SCHEMBL16986950 | 0.80 | JAK1 (0.70) | JAK1JAK2MAP3K5EGLN2TYK2 | |
| Cyclopropane SCHEMBL16986949 | 0.78 | PIK3CG (0.53) | JAK2 | |
| SCHEMBL3098201 | 0.74 | NUDT1 (0.62) | JAK1EGLN2JAK3 | |
| Cyclopropane SCHEMBL16986945 | 0.72 | MAP3K5 (0.73) | JAK1JAK2MAP3K5EGLN2TYK2 | |
| Cyclopropane SCHEMBL16986940 | 0.72 | JAK2 (0.72) | JAK1JAK2EGLN2TYK2 | |
| Cyclohexane SCHEMBL16986948 | 0.72 | JAK1 (0.53) | JAK1JAK2MAP3K5EGLN2TYK2 | |
| Cyclopropane SCHEMBL16986955 | 0.72 | JAK2 (0.61) | JAK1JAK2TYK2JAK3 | |
| Cyclopropane SCHEMBL16986954 | 0.71 | JAK1 (0.46) | JAK1JAK2MAP3K5TYK2 | |
| Cyclopropane SCHEMBL15655209 | 0.70 | JAK2 (0.69) | JAK1JAK2TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057158-B1 | TRIAZOLE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LTD (GB) | 2015-08-12 | — | — | EP | claimed |