Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 20/20 | 0.94 |
| ▸ | HTR2A | P28223 | 20/20 | 0.94 |
| ▸ | DRD3 | P35462 | 20/20 | 0.94 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1698750 | 1.00 | DRD2 (0.94) | DRD2HTR2ADRD3 | |
| SCHEMBL1698934 | 0.97 | DRD2 (1.00) | DRD2HTR2ADRD3 | |
| SCHEMBL12073708 | 0.97 | DRD2 (1.00) | DRD2HTR2ADRD3 | |
| SCHEMBL1698372 | 0.93 | DRD2 (1.00) | DRD2HTR2ADRD3 | |
| SCHEMBL12073619 | 0.93 | DRD2 (1.00) | DRD2HTR2ADRD3 | |
| SCHEMBL12073706 | 0.88 | DRD2 (1.00) | DRD2HTR2ADRD3 | |
| SCHEMBL15385215 | 0.88 | DRD2 (1.00) | DRD2HTR2ADRD3 | |
| SCHEMBL1698667 | 0.88 | DRD2 (1.00) | DRD2HTR2ADRD3 | |
| SCHEMBL12074374 | 0.86 | DRD2 (1.00) | DRD2HTR2ADRD3 | |
| SCHEMBL1698429 | 0.86 | DRD2 (1.00) | DRD2HTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582705-A1 | ANELLATED PYRIDINE COMPOUNDS AS DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-04-24 | — | — | EP | claimed |
| WO-2011161009-A1 | ANELLATED PYRIDINE COMPOUNDS AS DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-29 | — | — | WO | claimed |