Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | OGA | O60502 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | PARG | Q86W56 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16989145 | 0.91 | MAPK1 (0.42) | MAPK1SMN1; SMN2OGAHTTCCNE1 | |
| SCHEMBL16989149 | 0.82 | HTR2C (0.34) | MAPK1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL18237190 | 0.81 | SMN1; SMN2 (0.39) | MAPK1SMN1; SMN2OGAHTTCCNE1 | |
| SCHEMBL18476743 | 0.80 | MAPK1 (0.39) | MAPK1SMN1; SMN2OGAHTT | |
| SCHEMBL18476498 | 0.80 | MAPK1 (0.38) | MAPK1SMN1; SMN2OGAHTTCCNE1 | |
| SCHEMBL16989191 | 0.80 | MAPK1 (0.38) | MAPK1SMN1; SMN2OGAHTTCCNE1 | |
| SCHEMBL16989085 | 0.80 | MAPK1 (0.39) | MAPK1SMN1; SMN2OGAHTT | |
| SCHEMBL20244142 | 0.79 | CCNE1 (0.41) | MAPK1SMN1; SMN2OGAHTTCCNE1 | |
| SCHEMBL16989167 | 0.79 | CCNE1 (0.41) | MAPK1SMN1; SMN2OGAHTTCCNE1 | |
| SCHEMBL18476499 | 0.76 | CTSL (0.41) | MAPK1CCNE1CDK2CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150225389-A1 | THERAPEUTIC COMPOUNDS AND COMPOSITIONS | eXIthera Pharmaceuticals Inc. (US) | 2015-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225389-A1 | THERAPEUTIC COMPOUNDS AND COMPOSITIONS | KLK5, KLKB1, KLK2 | MAPK1 3025/4885SMN1; SMN2 4040/4885OGA 2405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.