Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.48 |
| ▸ | GCK | P35557 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15574633 | 0.90 | HDAC1 (0.60) | HDAC1HDAC6GSK3BALDH1A1SMN1; SMN2 | |
| SCHEMBL16990623 | 0.89 | P2RX3 (0.49) | HDAC1HDAC6GSK3BSMN1; SMN2L3MBTL1 | |
| SCHEMBL15573117 | 0.88 | DDR2 (0.56) | HDAC1HDAC6GSK3BALDH1A1SMN1; SMN2 | |
| SCHEMBL15573219 | 0.86 | GRM5 (0.52) | HDAC1HDAC6GSK3BSMN1; SMN2GCK | |
| SCHEMBL16990654 | 0.86 | HDAC1 (0.55) | HDAC1HDAC6GSK3BALDH1A1SMN1; SMN2 | |
| SCHEMBL15574905 | 0.84 | GCK (0.47) | GSK3BGCKRAB9ANPC1 | |
| SCHEMBL15575329 | 0.83 | KMT2A (0.60) | ALDH1A1SMN1; SMN2L3MBTL1TP53P2RX3 | |
| SCHEMBL15574560 | 0.83 | NPC1 (0.58) | SMN1; SMN2TP53RAB9ANPC1HTT | |
| SCHEMBL16990706 | 0.81 | RAF1 (0.62) | — | |
| SCHEMBL16990607 | 0.80 | MEN1 (0.53) | HDAC1HDAC6GSK3BP2RX3HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150225369-A1 | DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | MERCK PATENT GMBH (DE) | 2015-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225369-A1 | DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | DDR2, DDR1, DDRGK1 | HDAC1 2366/4885HDAC6 620/4885GSK3B 494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.