Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 7/20 | 0.58 |
| ▸ | DDR2 | Q16832 | 4/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 5/20 | 0.48 |
| ▸ | KDR | P35968 | 4/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | BCR | P11274 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | RARG | P13631 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15574177 | 0.92 | DDR2 (0.65) | RAF1DDR2GSK3BBRAFKDR | |
| SCHEMBL16990631 | 0.90 | RAF1 (0.68) | RAF1DDR2GSK3BBRAFKDR | |
| SCHEMBL16990626 | 0.90 | DDR2 (0.60) | RAF1DDR2P2RX3L3MBTL1 | |
| SCHEMBL15573094 | 0.89 | RAF1 (0.53) | RAF1DDR2GSK3BBRAFKDR | |
| SCHEMBL16990668 | 0.88 | DDR2 (0.60) | RAF1DDR2GSK3BRETFLT4 | |
| SCHEMBL16990638 | 0.87 | RAF1 (0.57) | RAF1DDR2BRAFKDRL3MBTL1 | |
| SCHEMBL16990616 | 0.87 | DDR2 (0.70) | RAF1DDR2BRAFKDRP2RX3 | |
| SCHEMBL15574850 | 0.83 | DDR2 (0.56) | RAF1DDR2GSK3BBRAFKDR | |
| SCHEMBL171051 | 0.83 | RAF1 (0.71) | RAF1DDR2GSK3BBRAFKDR | |
| SCHEMBL15574638 | 0.82 | DDR2 (0.67) | RAF1DDR2GSK3BBRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150225369-A1 | DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | MERCK PATENT GMBH (DE) | 2015-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225369-A1 | DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | DDR2, DDR1, DDRGK1 | RAF1 3072/4885DDR2 1/4885GSK3B 494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.