Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | GFER | P55789 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18300991 | 0.97 | MAPT (0.52) | MAPTKMT2AGAAMEN1CYP2C9 | |
| Bicarbonate SCHEMBL16991998 | 0.93 | MAPT (0.48) | MAPTKMT2AGAAMEN1CYP2C9 | |
| Bicarbonate SCHEMBL16991995 | 0.93 | MAPT (0.48) | MAPTKMT2AGAAMEN1CYP2C9 | |
| SCHEMBL27910608 | 0.84 | MAPT (0.51) | MAPTKMT2AGAAMEN1CYP2C9 | |
| SCHEMBL1334225 | 0.84 | SIRT6 (0.61) | MAPTKMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL20976848 | 0.84 | HIF1A (0.60) | MAPTKMT2AGAAMEN1GFER | |
| SCHEMBL16055881 | 0.82 | HIF1A (0.60) | MAPTKMT2AGAAMEN1CYP2C19 | |
| SCHEMBL25330719 | 0.82 | MAPT (0.46) | MAPTKMT2AGAAMEN1CYP2C9 | |
| SCHEMBL30195159 | 0.82 | MAPT (0.50) | MAPTKMT2AGAAMEN1CYP2C9 | |
| SCHEMBL12316348 | 0.81 | ALK (0.52) | MAPTKMT2AMEN1CYP2C19L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3104860-A1 | PHARMACEUTICAL COMPOUNDS | Cascadian Therapeutics, Inc. (US) | 2016-12-21 | — | — | EP | disclosed |
| WO-2015120390-A1 | PHARMACEUTICAL COMPOUNDS | ONCOTHYREON INC. (US) | 2015-08-13 | — | — | WO | disclosed |