Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 10/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1701511 | 1.00 | GPR84 (0.48) | GPR84KDM4EMEN1KMT2AALOX5 | |
| SCHEMBL10271796 | 0.84 | GPR84 (0.40) | GPR84KDM4EMEN1KMT2ACYP2C19 | |
| SCHEMBL15153967 | 0.81 | GPR84 (0.40) | GPR84MAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL1699489 | 0.81 | GPR84 (0.40) | GPR84MAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL15094683 | 0.80 | CYP1A2 (0.37) | KDM4EMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL15094522 | 0.80 | CYP1A2 (0.37) | KDM4EMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL1702028 | 0.80 | CYP1A2 (0.37) | KDM4EMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL251939 | 0.80 | SYK (0.39) | — | |
| SCHEMBL246921 | 0.80 | CCR1 (0.40) | KDM4EMEN1KMT2AALOX5MAPT | |
| SCHEMBL3297997 | 0.80 | CCR1 (0.40) | KDM4EMEN1KMT2AALOX5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588450-A1 | NAPHT- 2 -YLACETIC ACID DERIVATIVES TO TREAT AIDS | Gilead Sciences, Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003497-A1 | NAPHT- 2 -YLACETIC ACID DERIVATIVES TO TREAT AIDS | GILEAD SCIENCES, INC. (US) | 2012-01-05 | — | — | WO | disclosed |