Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 18/20 | 0.69 |
| ▸ | SRC | P12931 | 3/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.52 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.52 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16986321 | 0.90 | WEE1 (0.55) | WEE1SRCEGFRFGFR1FGFR2 | |
| SCHEMBL16986316 | 0.87 | WEE1 (0.69) | WEE1SRCEGFRFGFR1FGFR2 | |
| SCHEMBL16287539 | 0.87 | WEE1 (0.69) | WEE1SRCEGFRFGFR1FGFR2 | |
| SCHEMBL16986363 | 0.85 | WEE1 (0.52) | WEE1SRCEGFRFGFR1FGFR2 | |
| SCHEMBL16287166 | 0.82 | SRC (0.62) | WEE1SRCEGFRFGFR1FGFR2 | |
| SCHEMBL16986326 | 0.81 | WEE1 (0.63) | WEE1SRCEGFRFGFR1FGFR2 | |
| SCHEMBL16287869 | 0.80 | SRC (0.73) | WEE1SRCEGFRFGFR1FGFR2 | |
| SCHEMBL16986344 | 0.78 | ADRB2 (0.48) | WEE1MAPK14 | |
| SCHEMBL16986361 | 0.76 | FGFR1 (0.59) | WEE1SRCEGFRFGFR1FGFR2 | |
| SCHEMBL16986362 | 0.75 | FGFR1 (0.69) | WEE1SRCEGFRFGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015118110-A1 | PYRIDO[2,3-D]PYRIMIDINE-7(8H)-ONE DERIVATIVES FOR THE TREATMENT OF HEPATITIS C | INSTITUT QUÍMIC DE SARRIÁ, CETS FUNDACIÓ PRIVADA (ES) | 2015-08-13 | — | — | WO | disclosed |
| EP-2905024-A1 | Pyrido[2,3-d]pyrimidine-7(8H)-one derivatives for the treatment of infections caused by Flaviviridae | Institut Quimic De Sarriá Cets, Fundació Privada (ES) | 2015-08-12 | — | — | EP | disclosed |