Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 11/20 | 0.62 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16986374 | 0.78 | HRH4 (0.59) | HRH4HRH3 | |
| SCHEMBL9278859 | 0.71 | HRH4 (0.64) | HRH4 | |
| SCHEMBL16986349 | 0.71 | PIK3CA (0.46) | HRH4PIK3CA | |
| SCHEMBL4356738 | 0.71 | HRH4 (0.51) | HRH4HRH3 | |
| SCHEMBL16986317 | 0.69 | PIK3CA (0.43) | HRH4PIK3CA | |
| SCHEMBL4063426 | 0.68 | NOS1 (0.48) | HRH4PIK3CAHRH3 | |
| SCHEMBL938102 | 0.68 | HRH4 (0.55) | HRH4HRH3 | |
| SCHEMBL1896729 | 0.68 | PIK3CA (0.74) | PIK3CA | |
| SCHEMBL4359804 | 0.67 | HRH4 (0.68) | HRH4HRH3 | |
| SCHEMBL3364869 | 0.67 | HRH4 (0.80) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015118110-A1 | PYRIDO[2,3-D]PYRIMIDINE-7(8H)-ONE DERIVATIVES FOR THE TREATMENT OF HEPATITIS C | INSTITUT QUÍMIC DE SARRIÁ, CETS FUNDACIÓ PRIVADA (ES) | 2015-08-13 | — | — | WO | disclosed |
| EP-2905024-A1 | Pyrido[2,3-d]pyrimidine-7(8H)-one derivatives for the treatment of infections caused by Flaviviridae | Institut Quimic De Sarriá Cets, Fundació Privada (ES) | 2015-08-12 | — | — | EP | disclosed |