Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 14/20 | 0.69 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.64 |
| ▸ | INSR | P06213 | 4/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12826742 | 0.90 | LRRK2 (0.65) | LRRK2 | |
| SCHEMBL12826443 | 0.90 | LRRK2 (0.70) | LRRK2MAPK3INSRALK | |
| SCHEMBL12826706 | 0.88 | EGFR (0.55) | LRRK2MAPK3INSRALK | |
| SCHEMBL12826701 | 0.88 | LRRK2 (0.60) | LRRK2MAPK3INSRALK | |
| SCHEMBL18857294 | 0.88 | MAPK3 (0.82) | LRRK2MAPK3INSRALK | |
| SCHEMBL18857474 | 0.88 | MAPK3 (0.82) | LRRK2MAPK3INSRALK | |
| SCHEMBL18857572 | 0.88 | MAPK3 (0.82) | LRRK2MAPK3INSRALK | |
| SCHEMBL12826576 | 0.87 | LRRK2 (0.61) | LRRK2 | |
| SCHEMBL1465782 | 0.86 | LRRK2 (0.59) | LRRK2MAPK3INSRALK | |
| SCHEMBL16995435 | 0.86 | PTK2 (0.68) | LRRK2ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408752-B1 | SUBSTITUTED PYRIMIDINES FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INT (DE) | 2015-08-12 | — | — | EP | disclosed |