Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 6/20 | 0.68 |
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.67 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | BRD4 | O60885 | 2/20 | 0.55 |
| ▸ | PLK1 | P53350 | 1/20 | 0.55 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.55 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16995449 | 0.91 | PTK2 (0.57) | PTK2LRRK2AURKAAURKBBRD4 | |
| SCHEMBL12826703 | 0.91 | LRRK2 (0.67) | PTK2LRRK2AURKAAURKBBRD4 | |
| SCHEMBL12826573 | 0.90 | AURKA (0.70) | PTK2LRRK2AURKAAURKBBRD4 | |
| SCHEMBL12826742 | 0.89 | LRRK2 (0.65) | LRRK2 | |
| SCHEMBL12826705 | 0.89 | LRRK2 (0.64) | PTK2LRRK2AURKAAURKBBRD4 | |
| SCHEMBL12826445 | 0.88 | LRRK2 (0.63) | PTK2LRRK2AURKAAURKBBRD4 | |
| SCHEMBL12826702 | 0.87 | LRRK2 (0.62) | PTK2LRRK2AURKAAURKBBRD4 | |
| SCHEMBL12826576 | 0.87 | LRRK2 (0.61) | PTK2LRRK2AURKAAURKB | |
| SCHEMBL12826701 | 0.86 | LRRK2 (0.60) | PTK2LRRK2ALK | |
| SCHEMBL16995451 | 0.86 | LRRK2 (0.69) | LRRK2ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408752-B1 | SUBSTITUTED PYRIMIDINES FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INT (DE) | 2015-08-12 | — | — | EP | disclosed |