Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1699673 | 1.00 | KMT2A (0.42) | KMT2AMEN1LMNAMAPK1NPSR1 | |
| SCHEMBL1699439 | 0.96 | KMT2A (0.45) | KMT2AMEN1LMNAMAPK1NPSR1 | |
| SCHEMBL1699438 | 0.96 | KMT2A (0.45) | KMT2AMEN1LMNAMAPK1NPSR1 | |
| SCHEMBL13221596 | 0.82 | CA2 (0.51) | KMT2AMEN1LMNANPSR1MAPT | |
| SCHEMBL10296054 | 0.80 | MAPT (0.48) | KMT2AMEN1MAPK1NPSR1MAPT | |
| SCHEMBL11310922 | 0.80 | MAPT (0.48) | KMT2AMEN1MAPK1NPSR1MAPT | |
| SCHEMBL11310923 | 0.80 | MAPT (0.48) | KMT2AMEN1MAPK1NPSR1MAPT | |
| SCHEMBL2432378 | 0.79 | KMT2A (0.51) | KMT2AMEN1LMNAHTTSMN1; SMN2 | |
| SCHEMBL2432376 | 0.79 | KMT2A (0.51) | KMT2AMEN1LMNAHTTSMN1; SMN2 | |
| SCHEMBL8694090 | 0.79 | MEN1 (0.44) | KMT2AMEN1LMNAMAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013103738-A1 | NAPTHALENE ACETIC ACID DERIVATIVES AGAINST HIV INFECTION | GILEAD SCIENCES, INC. (US) | 2013-07-11 | — | — | WO | disclosed |
| EP-2588450-A1 | NAPHT- 2 -YLACETIC ACID DERIVATIVES TO TREAT AIDS | Gilead Sciences, Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003497-A1 | NAPHT- 2 -YLACETIC ACID DERIVATIVES TO TREAT AIDS | GILEAD SCIENCES, INC. (US) | 2012-01-05 | — | — | WO | disclosed |