Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3364550 | 0.87 | PTGDR2 (0.53) | HPGDSMN1; SMN2LMNARAB9AKMT2A | |
| SCHEMBL7371844 | 0.87 | PTGDR2 (0.56) | HPGDSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL16997486 | 0.86 | PTGDR2 (0.48) | HPGDSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL17973700 | 0.86 | PTGDR2 (0.68) | HPGDSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL2568322 | 0.84 | SMN1; SMN2 (0.59) | HPGDSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL5927172 | 0.84 | HPGD (0.52) | HPGDSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL6487232 | 0.84 | HPGD (0.52) | HPGDSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL8336977 | 0.84 | HTT (0.65) | HPGDSMN1; SMN2LMNAKDM4EMEN1 | |
| SCHEMBL27684806 | 0.84 | PTGDR2 (0.50) | HPGDSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL4600210 | 0.83 | HPGD (0.51) | HPGDSMN1; SMN2LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160332976-A1 | PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS | GILEAD SCIENCES, INC. | 2016-11-17 | — | — | US | disclosed |
| US-20160332977-A1 | PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS | GILEAD SCIENCES, INC. | 2016-11-17 | — | — | US | disclosed |
| US-20150225384-A1 | PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS | GILEAD SCIENCES, INC. | 2015-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160332976-A1 | PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS | KCNN2, KCNJ2, KCNN1 | HPGD 1696/4885SMN1; SMN2 834/4885LMNA 1766/4885 |
| US-20160332977-A1 | PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS | KCNN2, KCNJ2, KCNN1 | HPGD 1696/4885SMN1; SMN2 834/4885LMNA 1766/4885 |
| US-20150225384-A1 | PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS | KCNN2, KCNJ2, KCNN1 | HPGD 1696/4885SMN1; SMN2 834/4885LMNA 1766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.