⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1783085 | 1.00 | — | — | |
| SCHEMBL1783254 | 0.86 | — | — | |
| SCHEMBL9445820 | 0.77 | — | — | |
| SCHEMBL9445794 | 0.77 | — | — | |
| SCHEMBL16715768 | 0.74 | — | — | |
| SCHEMBL20981784 | 0.71 | — | — | |
| SCHEMBL13826368 | 0.67 | — | — | |
| SCHEMBL19416415 | 0.66 | — | — | |
| SCHEMBL11376640 | 0.66 | TRPA1 (0.38) | — | |
| Acetaldehyde SCHEMBL15874567 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3649133-B1 | ENGLERIN DERIVATIVES FOR TREATMENT OF CANCER | US HEALTH (US) | 2022-02-23 | — | — | EP | disclosed |
| EP-3649133-B1 | ENGLERIN DERIVATIVES FOR TREATMENT OF CANCER | US HEALTH (US) | 2022-02-23 | — | — | EP | disclosed |
| US-20210403470-A1 | NOVEL METHODS FOR PREPARATION OF SUBSTITUTED PYRIDINES AND RELATED NOVEL COMPOUNDS | WATKINS EDMOND BLAKE (US) | 2021-12-30 | — | — | US | disclosed |
| US-11117893-B2 | Methods for preparation of substituted pyridines and related novel compounds | UNION UNIVERSITY (US) | 2021-09-14 | — | — | US | disclosed |
| EP-3649133-A1 | ENGLERIN DERIVATIVES FOR TREATMENT OF CANCER | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services (US) | 2020-05-13 | — | — | EP | disclosed |
| US-20200140451-A1 | ENGLERIN DERIVATIVES FOR TREATMENT OF CANCER | THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2020-05-07 | — | — | US | disclosed |
| US-20200140451-A1 | ENGLERIN DERIVATIVES FOR TREATMENT OF CANCER | THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2020-05-07 | — | — | US | disclosed |
| US-20200095245-A1 | NOVEL METHODS FOR PREPARATION OF SUBSTITUTED PYRIDINES AND RELATED NOVEL COMPOUNDS | UNION UNIVERSITY | 2020-03-26 | — | — | US | disclosed |
| WO-2019010298-A1 | ENGLERIN DERIVATIVES FOR TREATMENT OF CANCER | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2019-01-10 | — | — | WO | disclosed |
| US-9676788-B2 | Aza-epoxy-guaiane derivatives and treatment of cancer | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES (US) | 2017-06-13 | — | — | US | disclosed |
| US-9676788-B2 | Aza-epoxy-guaiane derivatives and treatment of cancer | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES (US) | 2017-06-13 | — | — | US | disclosed |
| US-20160347764-A1 | AZA-EPOXY-GUAIANE DERIVATIVES AND TREATMENT OF CANCER | The United State of America, as represented by the Secretary, Department of Health and Human Service (US) | 2016-12-01 | — | — | US | disclosed |
| US-20160347764-A1 | AZA-EPOXY-GUAIANE DERIVATIVES AND TREATMENT OF CANCER | The United State of America, as represented by the Secretary, Department of Health and Human Service (US) | 2016-12-01 | — | — | US | disclosed |
| WO-2015120140-A1 | AZA-EPOXY-GUAIANE DERIVATIVES AND TREATMENT OF CANCER | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2015-08-13 | — | — | WO | disclosed |