Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ULK1 | O75385 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.34 |
| ▸ | PREP | P48147 | 1/20 | 0.33 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18382159 | 1.00 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2HCRTR2POLB | |
| SCHEMBL17001680 | 0.83 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2HCRTR2POLB | |
| SCHEMBL17001664 | 0.82 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2POLBTDP1 | |
| SCHEMBL18382116 | 0.82 | DRD2 (0.37) | NPC1RAB9ASMN1; SMN2HCRTR2POLB | |
| SCHEMBL20312939 | 0.82 | DRD2 (0.37) | NPC1RAB9ASMN1; SMN2HCRTR2POLB | |
| SCHEMBL18382059 | 0.81 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2POLBTDP1 | |
| SCHEMBL17001679 | 0.78 | SMN1; SMN2 (0.50) | NPC1RAB9ASMN1; SMN2HCRTR2POLB | |
| SCHEMBL17001678 | 0.78 | SMN1; SMN2 (0.50) | NPC1RAB9ASMN1; SMN2HCRTR2POLB | |
| SCHEMBL17001674 | 0.78 | SMN1; SMN2 (0.50) | NPC1RAB9ASMN1; SMN2HCRTR2POLB | |
| SCHEMBL17001673 | 0.77 | KDM4E (0.45) | NPC1RAB9ASMN1; SMN2HCRTR2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015118342-A1 | BICYCLIC AZA COMPOUNDS AS MUSCARINIC M1 RECEPTOR AGONISTS. | HEPTARES THERAPEUTICS LIMITED (GB) | 2015-08-13 | — | — | WO | disclosed |