Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 15/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.47 |
| ▸ | PDE4A | P27815 | 12/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3605697 | 0.85 | PDE4D (0.55) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL3616202 | 0.84 | PDE4A (0.59) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL3606207 | 0.83 | PDE4D (0.42) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL8635918 | 0.83 | PDE4D (0.69) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL8633365 | 0.82 | PDE4D (0.67) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL9269661 | 0.78 | PDE4D (0.46) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL9181365 | 0.78 | PDE4D (0.59) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL17011762 | 0.78 | PDE4D (0.58) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL18288862 | 0.77 | FPR2 (0.37) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL28052513 | 0.76 | SMN1; SMN2 (0.46) | PDE4DPDE4BPDE4APDE4CPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3105206-B1 | MORPHOLINE DERIVATIVES HAVING A SELECTIVE PDE4D INHIBITING ACTIVITY | UNIV DEGLI STUDI GENOVA (IT) | 2019-08-07 | — | — | EP | disclosed |
| EP-3105206-B1 | MORPHOLINE DERIVATIVES HAVING A SELECTIVE PDE4D INHIBITING ACTIVITY | UNIV DEGLI STUDI GENOVA (IT) | 2019-08-07 | — | — | EP | disclosed |
| US-10017480-B2 | Compounds having a selective PDE4D inhibiting activity | UNIVERSITA DEGLI STUDI DI GENOVA (IT) | 2018-07-10 | — | — | US | disclosed |
| US-10017480-B2 | Compounds having a selective PDE4D inhibiting activity | UNIVERSITA DEGLI STUDI DI GENOVA (IT) | 2018-07-10 | — | — | US | disclosed |
| US-10017480-B2 | Compounds having a selective PDE4D inhibiting activity | UNIVERSITA DEGLI STUDI DI GENOVA (IT) | 2018-07-10 | — | — | US | disclosed |
| EP-3105206-A1 | NEW COMPOUNDS HAVING A SELECTIVE PDE4D INHIBITING ACTIVITY | Universita' degli Studi di Genova (IT) | 2016-12-21 | — | — | EP | disclosed |
| US-20160355489-A1 | NEW COMPOUNDS HAVING A SELECTIVE PDE4D INHIBITING ACTIVITY | THE TRUSTEES OF COLUMBIA UNIVERSITY | 2016-12-08 | — | — | US | disclosed |
| US-20160355489-A1 | NEW COMPOUNDS HAVING A SELECTIVE PDE4D INHIBITING ACTIVITY | THE TRUSTEES OF COLUMBIA UNIVERSITY | 2016-12-08 | — | — | US | disclosed |
| US-20160355489-A1 | NEW COMPOUNDS HAVING A SELECTIVE PDE4D INHIBITING ACTIVITY | THE TRUSTEES OF COLUMBIA UNIVERSITY | 2016-12-08 | — | — | US | disclosed |
| WO-2015121212-A1 | NEW COMPOUNDS HAVING A SELECTIVE PDE4D INHIBITING ACTIVITY | UNIVERSITÀ DEGLI STUDI DI GENOVA (IT) | 2015-08-20 | — | — | WO | disclosed |
| WO-2015121212-A1 | NEW COMPOUNDS HAVING A SELECTIVE PDE4D INHIBITING ACTIVITY | UNIVERSITÀ DEGLI STUDI DI GENOVA (IT) | 2015-08-20 | — | — | WO | disclosed |
| EP-2907806-A1 | New compounds as selective PDE4D inhibitors | UNIVERSITA DEGLI STUDI DI GENOVA (IT) | 2015-08-19 | — | — | EP | disclosed |
| EP-2907806-A1 | New compounds as selective PDE4D inhibitors | UNIVERSITA DEGLI STUDI DI GENOVA (IT) | 2015-08-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160355489-A1 | NEW COMPOUNDS HAVING A SELECTIVE PDE4D INHIBITING ACTIVITY | PDE4A, PDE4D, PDE4B | PDE4D 2/4885PDE4B 3/4885PDE4A 1/4885 |
| US-10017480-B2 | Compounds having a selective PDE4D inhibiting activity | PDE4A, PDE4D, PDE2A | PDE4D 2/4885PDE4B 4/4885PDE4A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.