Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 4/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 3/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | HPGDS | O60760 | 2/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | IDH2 | P48735 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | HCK | P08631 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17004258 | 0.88 | SLC6A2 (0.34) | CHEK1ABL1 | |
| SCHEMBL17004209 | 0.83 | CHRNA7 (0.38) | CHRNA7KCNH2ROCK2PIK3CDPIK3CB | |
| SCHEMBL17004208 | 0.79 | CHRNA7 (0.37) | CHRNA7KCNH2CHEK1 | |
| SCHEMBL17004343 | 0.78 | USP30 (0.38) | CHRNA7KDR | |
| SCHEMBL17004194 | 0.78 | CHRNA7 (0.42) | CHRNA7KCNH2CHEK1 | |
| SCHEMBL1110452 | 0.77 | CHRNA7 (0.44) | CHRNA7KCNH2ROCK2HTR1APIK3CA | |
| SCHEMBL17004333 | 0.75 | FLT3 (0.33) | CHRNA7KDRPRKDC | |
| SCHEMBL17004331 | 0.74 | CDC7 (0.31) | PIK3CAMTOR | |
| SCHEMBL17004203 | 0.74 | SLC6A2 (0.36) | CHEK1ABL1 | |
| SCHEMBL17004227 | 0.73 | CHRNB4 (0.39) | CHRNA7KCNH2CHEK1PIK3CDHPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099795-B1 | AZAADAMANTANE DERIVATIVES AND THEIR USES AS NICOTINIC ACETYLCHOLINE RECEPTORS LIGANDS | ABBVIE BAHAMAS LTD (BS) | 2015-08-19 | — | — | EP | disclosed |