Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 7/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | PLAT | P00750 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | TYMP | P19971 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17004352 | 0.93 | PDE2A (0.52) | PDE2AHDAC3HDAC1HDAC2CCNA2 | |
| SCHEMBL17004318 | 0.83 | PDE2A (0.51) | PDE2AHDAC3HDAC1HDAC2CCNA2 | |
| SCHEMBL17004334 | 0.83 | PDE2A (0.57) | PDE2AHDAC3HDAC1HDAC2CCNA2 | |
| SCHEMBL937313 | 0.82 | PDE2A (0.64) | PDE2AHDAC3HDAC1HDAC2CCNA2 | |
| SCHEMBL17004349 | 0.82 | PDE2A (0.54) | PDE2AHDAC3HDAC1HDAC2CCNA2 | |
| SCHEMBL17004302 | 0.82 | PDE2A (0.50) | PDE2AHDAC3HDAC1HDAC2MAOB | |
| SCHEMBL935940 | 0.82 | PDE2A (0.62) | PDE2AHDAC3HDAC1HDAC2PIM1 | |
| SCHEMBL17004360 | 0.81 | PDE2A (0.55) | PDE2AHDAC3HDAC1HDAC2CCNA2 | |
| SCHEMBL2680452 | 0.81 | PDE2A (0.76) | PDE2AHDAC3HDAC1HDAC2SLC6A2 | |
| SCHEMBL17004369 | 0.81 | PDE2A (0.51) | PDE2AHDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2456440-B1 | QUINOLINONE PDE2 INHIBITORS | MERCK SHARP & DOHME (US) | 2015-08-19 | — | — | EP | claimed |