Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.51 |
| ▸ | FYN | P06241 | 9/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16672245 | 0.84 | CHEK2 (0.55) | FYNMAP4K4CHEK2 | |
| SCHEMBL17004633 | 0.82 | KCNH2 (0.53) | KCNH2MAP4K4 | |
| SCHEMBL19086089 | 0.78 | LRRK2 (0.60) | — | |
| SCHEMBL13837101 | 0.77 | KCNH2 (0.59) | KCNH2FYNMAP4K4CHEK2TGFBR1 | |
| SCHEMBL17004628 | 0.73 | FYN (0.73) | KCNH2FYNTGFBR1ACVR1 | |
| SCHEMBL13837178 | 0.72 | KCNH2 (0.70) | KCNH2FYNMAP4K4CHEK2TGFBR1 | |
| SCHEMBL2226033 | 0.72 | FYN (0.76) | KCNH2FYNMAP4K4CHEK2TGFBR1 | |
| SCHEMBL16530537 | 0.72 | JAK2 (0.59) | — | |
| SCHEMBL12518229 | 0.71 | KCNH2 (0.79) | KCNH2FYNMAP4K4CHEK2TGFBR1 | |
| SCHEMBL19086085 | 0.70 | LRRK2 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2526090-B1 | NEW ANTI-MALARIAL AGENTS | MEDICINES FOR MALARIA VENTURE MMV (CH) | 2015-08-19 | — | — | EP | claimed |